Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients

Parkinsonism & Related Disorders
Gabriella SantangeloSabina Pappatà

Abstract

Apathy is a neuropsychiatric symptom in Parkinson's Disease (PD) which has a negative impact on quality of life and might be related in part to damage of presynaptic dopaminergic system. Little is known about relationship between striatal dopamine levels and apathy in PD patients without dementia and/or depression. The aim of the present study was to investigate the relationship between "pure apathy" and striatal dopamine uptake in untreated, drug-naïve PD patients without clinically significant dementia and/or depression. Fourteen PD patients with pure apathy and 14 PD patients without apathy, matched for age, side of motor symptoms at onset, motor disability and disease duration, underwent both neuropsychological and behavioral examination including self-rated version of the Apathy Evaluation Scale (AES-S). All patients underwent 123 I-FP-CIT (DaT-SCAN) SPECT to assess dopamine transporter (DAT) striatal uptake. PD patients with apathy showed lower DAT levels in the striatum than non-apathetic patients. After Bonferroni correction the difference between groups was significant in the right caudate. Apathy is associated with reduced striatal dopamine transporter levels, independent of motor disability and depression in non-deme...Continue Reading

References

Jan 1, 1991·The Journal of Neuropsychiatry and Clinical Neurosciences·R S Marin
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleR B Innis
Nov 24, 2004·Trends in Cognitive Sciences·Matthew M BotvinickCameron S Carter
Feb 18, 2005·Brain : a Journal of Neurology·Philippe RemyDavid Brooks
Dec 9, 2008·Behavioural Brain Research·Jessica A GrahnAdrian M Owen
Apr 13, 2010·Neuropsychology Review·Alice Cronin-Golomb
Jul 23, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Julián Benito-LeónUNKNOWN ANIMO Study Group
Jan 13, 2012·Neuroepidemiology·Esther CuboUNKNOWN ANIMO Study Group
Apr 16, 2013·Journal of Geriatric Psychiatry and Neurology·Erica HarrisRaymon Durso
Sep 26, 2014·Neurology·Gabriel H RobertDominique Drapier

❮ Previous
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Citations

Jan 8, 2016·Journal of Neural Transmission·Marina PicilloMaria Teresa Pellecchia
Jan 1, 2016·Parkinsonism & Related Disorders·Su Jin ChungYoung H Sohn
Oct 18, 2015·Neurology·Anhar Hassan, Eduardo E Benarroch
May 5, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M-C WenE K Tan
Aug 20, 2016·Journal of the Neurological Sciences·Kota SatoKoji Abe
Aug 20, 2016·Brain : a Journal of Neurology·Audrey MailletStéphane Thobois
Apr 23, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Gabriella SantangeloFrancesca Trojsi
Feb 19, 2017·Parkinsonism & Related Disorders·Marina PicilloMaria Teresa Pellecchia
Dec 7, 2017·Frontiers in Behavioral Neuroscience·Jonathan Del-MonteMarie C Gély-Nargeot
Jul 24, 2018·The International Journal of Neuroscience·Hiroo TerashiHitoshi Aizawa
Nov 27, 2018·International Journal of Geriatric Psychiatry·Hideki KanemotoManabu Ikeda
Sep 1, 2017·Brain Imaging and Behavior·Mikaeel ValliAntonio P Strafella
Jul 4, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PicilloUNKNOWN PRIAMO study group
Oct 12, 2018·Journal of Movement Disorders·Hwa Reung LeeJong Sam Baik
Nov 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Chiara BaianoGabriella Santangelo
Sep 28, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Byoung Seok YeYoung Ho Sohn
Jan 11, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Parunyou JulayanontNikolaus R McFarland
Jul 24, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L RicciardiM Bologna
Nov 12, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Soo Bin ParkJae Seung Kim
Feb 8, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Simona RaimoGabriella Santangelo
Jul 6, 2019·European Journal of Nuclear Medicine and Molecular Imaging·I Navalpotro-GomezMaria C Rodriguez-Oroz
Aug 14, 2019·Cells·Giovanni Palermo, Roberto Ceravolo
Mar 17, 2020·Journal of Neural Transmission·Sofia CuocoMaria Teresa Pellecchia
Jul 5, 2018·Brain Imaging and Behavior·Avner ThalerUNKNOWN LRRK2 Ashkenazi Jewish consortium
Oct 23, 2019·Journal of Geriatric Psychiatry and Neurology·Monique A PimontelFaith M Gunning
Apr 5, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Anna CastriotoPaul Krack
Aug 20, 2017·Current Neurology and Neuroscience Reports·Stephane ThoboisEmmanuel Broussolle
Mar 1, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marjan Jahanshahi, John C Rothwell
Feb 12, 2019·Restorative Neurology and Neuroscience·LingYu ZhangHuiFang Shang
Nov 1, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yoon-Sang OhJoong-Seok Kim
Feb 25, 2021·Journal of Geriatric Psychiatry and Neurology·Jared T HinkleGregory M Pontone
Feb 27, 2021·Frontiers in Aging Neuroscience·Ruwei OuHuifang Shang
Jul 28, 2016·Neuropharmacology·Melissa M ContiChristopher Bishop
Aug 19, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaoxue ShiShiyu Hu
Oct 22, 2020·Dementia and Geriatric Cognitive Disorders Extra·Niki UdoIchiro Kusumi

❮ Previous
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