Apathy Is Associated With Ventral Striatum Volume in Schizophrenia Spectrum Disorder

The Journal of Neuropsychiatry and Clinical Neurosciences
Robert M RothAndrew J Saykin

Abstract

Apathy is prevalent in schizophrenia, but its etiology has received little investigation. The ventral striatum (VS), a key brain region involved in motivated behavior, has been implicated in studies of apathy. We therefore evaluated whether apathy is associated with volume of the VS on MRI in 23 patients with schizophrenia using voxel-based morphometry. Results indicated that greater self-reported apathy severity was associated with smaller volume of the right VS even when controlling for age, gender, depression, and total gray matter volume. The finding suggests that apathy is related to abnormality of brain circuitry subserving motivated behavior in patients with schizophrenia.

Citations

Jul 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A S AvedisovaR V Zakharova
Nov 8, 2017·International Journal of Geriatric Psychiatry·Fernando CaravaggioAriel Graff-Guerrero
Jun 14, 2020·Neuroscience and Biobehavioral Reviews·Indrit BègueMatthias Kirschner
Sep 16, 2020·Schizophrenia Research·Achim BurrerMatthias Kirschner
Aug 1, 2021·Journal of Psychiatric Research·AmirHussein AbdolalizadehAmir Sasan Bayani Ershadi

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