Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington's Disease.

Journal of the International Neuropsychological Society : JINS
Maria B MisiuraPREDICT-HD Investigators & Working Group

Abstract

Apathy is a debilitating symptom of Huntington's disease (HD) and manifests before motor diagnosis, making it an excellent therapeutic target in the preclinical phase of Huntington's disease (prHD). HD is a neurological genetic disorder characterized by cognitive and motor impairment, and psychiatric abnormalities. Apathy is not well characterized within the prHD. In previous literature, damage to the caudate and putamen has been correlated with increased apathy in other neurodegenerative and movement disorders. The objective of this study was to determine whether apathy severity in individuals with prHD is related to striatum volumes and cognitive control. We hypothesized that, within prHD individuals, striatum volumes and cognitive control scores would be related to apathy. We constructed linear mixed models to analyze striatum volumes and cognitive control, a composite measure that includes tasks assessing with apathy scores from 797 prHD participants. The outcome variable for each model was apathy, and the independent variables for the four separate models were caudate volume, putamen volume, cognitive control score, and motor symptom score. We also included depression as a covariate to ensure that our results were not sole...Continue Reading

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Citations

Dec 31, 2020·Cell Reports Medicine·Kelly J AtkinsTrevor T-J Chong
Dec 29, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Jihene MatmatiPhilippe Allain

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