Apathy: prevalence, associated factors, and prognostic value among frail, older inpatients

Journal of the American Medical Directors Association
Eeva H HölttäKaisu H Pitkälä

Abstract

The association of apathy with Alzheimer disease and other dementias and caregiver burden has been examined in a number of studies; however, less is known about its relationship with delirium and mortality. We aimed to investigate the prevalence, relationship with delirium and dementia, and prognostic value of apathy in an elderly and frail inpatient population. The cohort included 425 patients in acute geriatric wards and in 7 nursing homes in Helsinki (1999-2000). Demographic factors, physical functioning, diagnoses, and drugs were assessed with special reference for dementia, delirium, and apathy. Mortality was registered from central registers. Of the patients, 98 (23.1%) suffered from apathy, and it was more frequent among men (32% versus 21% women, P = .037 ). There was no difference in mean age, number of comorbidities, or in the mean number of medications between those with and without apathy; however, those with apathy had lower mean MMSE points (9.2 versus 14.0 without apathy, P < .001), more often severe dementia according to Clinical Dementia Rating, and higher dependence in activities of daily living (P = .001). Furthermore, patients with apathy were more often suffering from delirium (37.8% versus 21.1%, P ≤ .001)...Continue Reading

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Citations

Jan 1, 2013·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Hideyuki Hattori
Jan 10, 2013·The Journal of Nutrition, Health & Aging·J E Morley
Nov 30, 2013·Journal of the American Medical Directors Association·Barbara J Messinger-RapportJohn E Morley
Oct 1, 2013·Journal of the American Medical Directors Association·John E Morley
Aug 6, 2013·Journal of the American Medical Directors Association·Joseph H Flaherty, John E Morley
Jun 5, 2013·Journal of the American Medical Directors Association·Theodore K Malmstrom, John E Morley
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