Nov 17, 2019

Apathy rating scores and β-amyloidopathy in patients with Parkinson disease at risk for cognitive decline

Neurology
Zhi ZhouNicolaas I Bohnen

Abstract

To determine whether β-amyloidopathy correlates with apathy rating scores independently of mood changes and other neurodegenerative processes in Parkinson disease (PD). In this cross-sectional study, patients with PD (n = 64, 48 male and 16 female, mean age 69.2 ± 6.7 years, Hoehn & Yahr stage 2.7 ± 0.5, Montreal Cognitive Assessment score 25.3 ± 3.0) underwent [11C]Pittsburgh compound B β-amyloid, [11C]dihydrotetrabenazine vesicular monoamine transporter type 2 (VMAT2), and [11C]methyl 4 piperidinyl propionate acetylcholinesterase brain PET imaging and clinical assessments, including the Marin Apathy Evaluation Scale, Clinician Version. Patients were recruited on the basis of having at least 1 risk factor for PD dementia, but they were excluded if they had dementia. Mean apathy rating score was 25.4 ± 6.4, reflecting predominantly subclinical apathy. Apathy rating scale scores correlated with amyloid binding, cognitive, depressive, and anxiety scores but not significantly with age, duration of disease, striatal VMAT2, or cholinergic binding. Multiple regression analysis model (p < 0.0001) showed significant regressor effects for global β-amyloid burden (p = 0.0038) with significant covariate effects for global cognitive z scor...Continue Reading

  • References43
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References

  • References43
  • Citations1

Mentioned in this Paper

Inferior Frontal Sulcus (Human Only)
SLC18A1 gene
Brain
ACHE
Evaluation
SLC18A2 protein, human
Clinician - Confidentiality
Beta-galactosidase Activity
Cross-Sectional Studies
Binding (Molecular Function)

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