Nov 17, 2019

Apathy rating scores and β-amyloidopathy in patients with Parkinson disease at risk for cognitive decline

Zhi ZhouNicolaas I Bohnen


To determine whether β-amyloidopathy correlates with apathy rating scores independently of mood changes and other neurodegenerative processes in Parkinson disease (PD). In this cross-sectional study, patients with PD (n = 64, 48 male and 16 female, mean age 69.2 ± 6.7 years, Hoehn & Yahr stage 2.7 ± 0.5, Montreal Cognitive Assessment score 25.3 ± 3.0) underwent [11C]Pittsburgh compound B β-amyloid, [11C]dihydrotetrabenazine vesicular monoamine transporter type 2 (VMAT2), and [11C]methyl 4 piperidinyl propionate acetylcholinesterase brain PET imaging and clinical assessments, including the Marin Apathy Evaluation Scale, Clinician Version. Patients were recruited on the basis of having at least 1 risk factor for PD dementia, but they were excluded if they had dementia. Mean apathy rating score was 25.4 ± 6.4, reflecting predominantly subclinical apathy. Apathy rating scale scores correlated with amyloid binding, cognitive, depressive, and anxiety scores but not significantly with age, duration of disease, striatal VMAT2, or cholinergic binding. Multiple regression analysis model (p < 0.0001) showed significant regressor effects for global β-amyloid burden (p = 0.0038) with significant covariate effects for global cognitive z scor...Continue Reading

  • References43
  • Citations1


  • References43
  • Citations1

Mentioned in this Paper

Inferior Frontal Sulcus (Human Only)
SLC18A1 gene
SLC18A2 protein, human
Clinician - Confidentiality
Beta-galactosidase Activity
Cross-Sectional Studies
Binding (Molecular Function)

Related Feeds

Alzheimer's Disease: Abeta

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Kathy DujardinLuc Defebvre
Tijdschrift voor psychiatrie
P Eikelenboom
© 2020 Meta ULC. All rights reserved