Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway

Cancer Cell International
Bin WeiQiang Xu

Abstract

Esophageal cancer is the sixth leading cause of cancer-related mortality worldwide, which is partially due to limited progress of therapy. Apatinib, an inhibitor of VEGFR2, has a promising antitumor effect on malignancies. However, the underlying mechanism of its antitumor effect on esophageal cancer remains poorly understood. Eighteen pairs of frozen esophageal cancer and their para-cancer samples and 25 paraffin specimens from advanced esophageal cancer patients treated with cisplatin-based regimen were collected. The effects of apatinib on cell growth, cell apoptosis, cell cycle and invasion/migration of esophageal cancer cells were assessed. Bioinformatics, luciferase reporter, immunoprecipitation and immunofluorescence assays were conducted for mechanic investigation. Quantitative RT-PCR, western blotting and immunohistochemistry were used to measure the expression of functional genes. Xenograft tumor growth of mice was performed. We found that VEGFR2 was highly expressed in esophageal cancer and associated with poor efficacy of cisplatin-based treatment. Apatinib displayed profound actions against tumor cell growth of human esophageal cancer via promoting cell apoptosis and cell cycle arrest. Also, apatinib displayed the ...Continue Reading

References

Dec 26, 2001·Nucleic Acids Research·Minoru KanehisaAkihiro Nakaya
Feb 9, 2007·The Journal of Biological Chemistry·Dexing FangZhimin Lu
Apr 18, 2012·Chinese Journal of Cancer·Han-Ze ZhangHong-Bing Shen
Oct 27, 2012·The Annals of Thoracic Surgery·Sheraz R MarkarDonald E Low
Nov 22, 2012·Cold Spring Harbor Perspectives in Biology·Jennifer L Stamos, William I Weis
Feb 5, 2013·Lancet·Arjun PennathurJames D Luketich
Mar 8, 2014·International Journal of Cancer. Journal International Du Cancer·Xichun HuChunmei Liao
Jul 2, 2014·Nature Reviews. Drug Discovery·Michael Kahn
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Apr 4, 2017·OncoTargets and Therapy·Zhengbo SongYiping Zhang
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Sep 2, 2017·OncoTargets and Therapy·Jianqiang Li, Lifen Wang
Dec 1, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zhijian JinWeihua Qiu
Dec 12, 2017·Biochemical and Biophysical Research Communications·Bingxin ZhengWei Guo
Dec 13, 2017·Journal of Biosciences·Raju Kumar, Murali D Bashyam
Mar 2, 2018·Journal of Translational Medicine·Manman DengBing Xu
Jul 28, 2018·OncoTargets and Therapy·Deze ZhaoXiaochun Zhang
Apr 13, 2019·Journal of Experimental & Clinical Cancer Research : CR·N A SeebacherA M Merlot
Jul 3, 2019·Cancers·Sara El-SahliSheng Liu
Aug 14, 2019·The Journal of Clinical Investigation·Zining WangXiaojun Xia

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
flow cytometry
electrophoresis
Assay
coimmunoprecipitation
xenograft
xenografts
ubiquitination

Software Mentioned

UALCAN
SPSS
ModFit

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.