Abstract
Endometrial carcinoma, generally, has a good prognosis. However, in some patients, the tumor appears to behave very aggressively, a course that cannot be explained with histopathological characteristics. More insight into the molecular background can be valuable to clarify these differences in tumor behavior. The three components associated with the Wnt pathway--i.e., adenomatous polyposis coli (APC), beta-catenin, and E-cadherin--were evaluated in a case-control study of 28 patients with stage-I endometrial carcinomas to determine their involvement in the development of recurrent disease. Mutation analysis of the mutation cluster region of the APC gene, determination of gene promoter methylation status of the APC-1A and E-cadherin genes, and immunohistochemical analysis of APC, E-cadherin, and beta-catenin were performed using paraffin-embedded tumor tissue. Twenty-one APC gene mutations were detected in 12 of 28 (43%) patients. Only three mutations would result in a stopcodon in the APC gene. APC gene promoter methylation was assessed in 12 of 28 (43%) patients. APC immunostaining was absent in two of 24 (8.3%) patients. The occurrence of APC mutations, APC gene promoter methylation, and APC immunostaining were not predictive...Continue Reading
References
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
May 1, 1994·Gynecologic Oncology·N SakuragiS Fujimoto
Apr 1, 1996·The British Journal of Surgery·W G Jiang
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Nov 1, 1996·The British Journal of Surgery·S TamuraM Monden
Sep 4, 1998·Science·T C HeK W Kinzler
Mar 17, 1999·Japanese Journal of Cancer Research : Gann·K KobayashiR Kudo
Mar 31, 1999·Trends in Biochemical Sciences·G Christofori, H Semb
May 18, 1999·Molecular Medicine Today·P Guilford
Jul 20, 1999·Molecular Carcinogenesis·H NeiR Kudo
Aug 6, 1999·The American Journal of Pathology·C GamalloA Armas
Aug 25, 1999·Histopathology·D C Mangham, P G Isaacson
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P J Morin
Aug 22, 2000·Oncogene·T TsuchiyaS J Meltzer
Aug 26, 2000·Cytokine & Growth Factor Reviews·T Akiyama
Oct 26, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P W SchlosshauerL H Ellenson
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·S DroufakouI R Hart
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·U KämmererP Ruck
May 31, 2001·The Journal of Cell Biology·C J GottardiB M Gumbiner
Sep 25, 2001·The Journal of Pathology·A M JubbP Quirke
Sep 25, 2001·Molecular Carcinogenesis·D NojimaR Dahiya
Sep 26, 2001·Cancer·A T PakilitP A Ganz
Dec 26, 2001·Cancer·B V KallakuryJ S Ross
Mar 20, 2002·Cancer·Hsiao Wen ChangAnthonyPoWing Yuen
Mar 29, 2002·Cancer·Richard B WilderJames D Cox
Apr 17, 2002·Virchows Archiv : an International Journal of Pathology·Xingpei HaoIan C Talbot
Apr 23, 2002·Human Mutation·Bostjan HumarParry Guilford
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Fodde
Jul 20, 2002·Life Sciences·Xi-Chun HuLouis W C Chow
Oct 3, 2002·Gastroenterology·Mario HermsenGerrit Meijer
Nov 20, 2002·Oncogene·Gema Moreno-BuenoJosé Palacios
Feb 6, 2003·Cancer·Tsuyoshi SaitoRyuichi Kudo
Mar 14, 2003·The Journal of Pathology·Gema Moreno-BuenoJosé Palacios
Dec 9, 2003·Mechanisms of Ageing and Development·Liang LiuTrygve O Tollefsbol
Citations
Sep 1, 1991·Biological Trace Element Research·J P Van Wouwe, L van Zuylen
Jun 14, 2005·Familial Cancer·Reetta KariolaMinna Nyström
Mar 21, 2012·Oncogene·A YeramianX Matias-Guiu
Mar 3, 2011·Cancer Research·Pradeep S TanwarJose M Teixeira
Feb 8, 2014·Virchows Archiv : an International Journal of Pathology·Xavier Matias-Guiu, Ben Davidson
Oct 4, 2015·Gynecologic Oncology·C E FordN Hacker
Jul 5, 2011·Molecular and Cellular Endocrinology·Paul H van der HorstLeen J Blok
Jan 27, 2012·Histopathology·Maria SantacanaXavier Matias-Guiu
Nov 11, 2009·Cancer Science·Atanas IgnatovRegine Schneider-Stock
Feb 24, 2015·Pathology, Research and Practice·Andrzej SemczukTomasz Rechberger
May 5, 2017·Epigenomics·Carla BartoschCarmen Jerónimo
Nov 10, 2011·São Paulo Medical Journal = Revista Paulista De Medicina·Marina de Pádua Nogueira MenezesWagner José Gonçalves
Jun 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Andrzej WincewiczMariola Sulkowska
Jun 15, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Meng Hua Tao, Jo L Freudenheim
Sep 27, 2013·Oncology Reports·Roman FiolkaJan Danko
Dec 14, 2011·Expert Review of Anticancer Therapy·Thanh H DellingerRandall F Holcombe
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yongyi WangLeen J Blok