Apc gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response

Bioscience Reports
Xian-Liang LaiZhi-Hua Chen

Abstract

Background: Intracranial aneurysm (IA) is a critical acquired cerebrovascular disease that may cause subarachnoid hemorrhage, and nuclear factor-κB (NF-κB)-mediated inflammation is involved in the pathogenesis of IA. Adenomatous polyposis coli (Apc) gene is a tumor suppressor gene associated with both familial and sporadic cancer. Herein, the purpose of our study is to validate effect of Apc gene on IA formation and rupture by regulating the NF-κB signaling pathway mediated inflammatory response. Methods: We collected IA specimens (from incarceration of IA) and normal cerebral arteries (from surgery of traumatic brain injury) to examine expression of Apc and the NF-κB signaling pathway related factors (NF-κB p65 and IκBα). ELISA was used to determine levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β (IL-1β), and IL-6. IA model was established in rats, and Apc-siRNA was treated to verify effect of Apc on IA formation and rupture. Next, regulation of Apc on the NF-κB signaling pathway was investigated. Results: Reduced expression of Apc and IκBα, and increased expression of NF-κB p65 were found in IA tissues. MCP-1, TNF-α, IL-1β, and IL-6 exhibited higher levels in unruptur...Continue Reading

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Citations

Apr 3, 2020·Molecular Biology Reports·George I LambrouSpiros Vlahopoulos
Aug 18, 2020·Cellular and Molecular Neurobiology·Zhixian JiangBingyu Li
Oct 20, 2020·Frontiers in Physiology·Romain MenetAyman ElAli
Jan 28, 2021·Neurosurgical Review·Vincent M TutinoJohn Kolega
Aug 3, 2021·Frontiers in Molecular Biosciences·Xin ChenShuo Wang

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Methods Mentioned

BETA
reverse
PCR
electrophoresis
ELISA

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