APC in cell migration

Advances in Experimental Medicine and Biology
Sandrine Etienne-Manneville

Abstract

Adenomatous Polyposis Coli (APC) is a tumor suppressor protein involved in the initiation and progression of colon cancer. The most widely accepted function ofAPC is to participate to the Wnt signaling pathway, by downregulating beta-catenin and thereby controlling gene transcription and cell proliferation. However, APC is clearly a multifunctional protein whose loss contributes to tumor formation in multiple ways. Regulation of APC localization during cell migration and the ability of APC to bind multiple polarity proteins and microtubule-associated molecules support the idea that APC plays a key role in directed cell migration and that this function may contribute to its tumour suppressor activity.

Citations

Oct 20, 2011·The Journal of Pathology·Annabelle LewisIan Tomlinson
Feb 6, 2013·The Journal of Cell Biology·Yasuhisa SakamotoSandrine Etienne-Manneville
Dec 15, 2015·Molecular Biology of the Cell·Kate M MillsBeric R Henderson
Jan 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kenji SugiokaHitoshi Sawa
Jul 24, 2013·Annual Review of Cell and Developmental Biology·Sandrine Etienne-Manneville
Jun 5, 2015·The FEBS Journal·Yael Maizels, Gabi Gerlitz
Apr 21, 2019·Cells·Tim Hohmann, Faramarz Dehghani
Sep 30, 2016·Scientific Reports·Santosh Kumar YadavJomon Joseph
Jun 21, 2017·Biological Reviews of the Cambridge Philosophical Society·Antonia ThielPhilipp Mayer-Kuckuk
Jul 8, 2020·International Journal of Molecular Sciences·Lavinia CasatiValeria Sibilia
Apr 2, 2011·Rejuvenation Research·Anthony OttoKetan Patel
Jan 4, 2017·Journal of Cell Science·Benjamin P Bouchet, Anna Akhmanova
May 11, 2021·Frontiers in Molecular Biosciences·Xiuyan YangShaoyong Lu
Oct 10, 2021·Biomedical Journal·Marta MastrogiovanniAndrés Alcover

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