APE1/Ref-1: versatility in progress

Antioxidants & Redox Signaling
Byeong Hwa Jeon, Kaikobad Irani

Abstract

Apurinic/apyrimidinic endonuclease1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression. Over the past decade and a half, knowledge of the biological functions, interactions, mechanisms of action, and regulation of the protein APE1/Ref-1 has grown exponentially. The multifunctional nature of APE1/Ref-1 is uncovering and has been extensively studied in the cellular response against oxidative stress. Recent evidence shows a biological role of APE1/Ref-1 can be modulated by the different post-translational modification. Because of APE1/Ref-1 importance to genomic stability and cell survival, APE1/Ref-1 is focused as the leading therapeutic target molecule for the oxidative stress condition or pathologic conditions such as cancer. This forum, dedicated to APE1/Ref-1, provides ample testimony that even though we have learned a great deal about APE1/Ref-1 over the past 15-plus years, our knowledge still constitutes the tip of the iceberg when it comes to understanding this versatile protein.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B DempleD S Chen
Oct 9, 2004·Circulation Research·Byeong Hwa JeonKaikobad Irani
Dec 6, 2005·Cardiovascular Research·Cuk Seong KimByeong Hwa Jeon
Jul 3, 2007·Free Radical Biology & Medicine·Narasimman GurusamyDipak K Das
Aug 22, 2008·Antioxidants & Redox Signaling·Aditi BapatMark R Kelley
Nov 4, 2008·Antioxidants & Redox Signaling·Gianluca TellMark R Kelley

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Citations

May 28, 2016·Chonnam Medical Journal·Sunga ChoiByeong Hwa Jeon
May 28, 2016·International Neurourology Journal·Yu Ran LeeByeong Hwa Jeon
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·David K WoodBevin P Engelward

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