Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Liangli JinZhi Wang


This study investigated the effect of apela on renal function and anti-inflammatory effect on whole body and kidney tissue in mice with type I cardiorenal syndrome (CRS). The murine type I CRS model was established and apela was subcutaneously infused for two weeks. Cardiac and renal functions were evaluated by echocardiography and blood biochemistry, respectively. The systemic and renal inflammatory responses were examined with molecular biological and histological methods. Human renal glomerular endothelial cells (RGECs) were used to evaluate the adhesion effect of monocytes in vitro. Compared to mice from the control group (CRS + vehicle), the plasma levels of N-terminal pro-brain natriuretic peptide, blood urea nitrogen and creatinine were significantly decreased, while the mean left ventricular ejection fraction was increased in apela-treated CRS mice at the 4th week. The expression of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α) in the circulation and kidney was decreased in apela-treated mice compared with control mice, and apela improved cardio-renal pathology in mice with type I CRS. Additionally, Apela significantly suppressed the expression of MCP-1, TNF-α, intercellular adhesion mol...Continue Reading


Oct 30, 1998·Biochemical and Biophysical Research Communications·K TatemotoM Fujino
Feb 13, 2001·Kidney International·C Guijarro, J Egido
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David Sanz-RosaVictoria Cachofeiro
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
Jul 21, 2011·Nature Immunology·Andrea OeckinghausSankar Ghosh
Jul 4, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Lanfang LiJian-Xiong Chen
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Oct 31, 2013·American Journal of Respiratory Cell and Molecular Biology·Ying MengXu Li
Dec 10, 2013·Developmental Cell·Serene C ChngBruno Reversade
Jan 11, 2014·Science·Andrea PauliAlexander F Schier
Mar 10, 2015·Biochimica Et Biophysica Acta·Hong ChenKun Huang
Apr 30, 2016·Journal of the American College of Cardiology·Peter C WestmanStephen E Epstein
May 21, 2016·Renal Failure·Burak BircanHüseyin Fatih Gül
Nov 26, 2016·The Medical Clinics of North America·Peminda K CabandugamaJames R Sowers
Jun 7, 2017·Journal of the American Society of Nephrology : JASN·Hong ChenKun Huang
Jul 21, 2017·Cardiology Research·Poornima VinodRupesh Raina
Aug 5, 2017·Critical Care Medicine·David CoquerelOlivier Lesur
Aug 9, 2017·Current Heart Failure Reports·Sameer Kurmani, Iain Squire
Mar 10, 2018·Cleveland Clinic Journal of Medicine·Guramrinder S ThindJeffrey L Wilt
Sep 21, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hailin ZhangXiaoxia Kong
Oct 13, 2018·Advances in Chronic Kidney Disease·Alberto Palazzuoli, Gaetano Ruocco
Dec 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nisha SharmaAnil Bhanudas Gaikwad
Feb 28, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Victor F ÁvilaClarice K Fujihara
Mar 12, 2019·Circulation·Janani RangaswamiUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Jul 3, 2019·Cardiorenal Medicine·Anna ClementiClaudio Ronco
Jul 8, 2019·Cardiology Clinics·Ujjala KumarPranav S Garimella
Jul 14, 2019·The Canadian Journal of Cardiology·Haran YogasundaramGavin Y Oudit
Sep 7, 2019·Journal of Hypertension·Demetrios V VlahakosGiuseppe Mancia
Nov 19, 2019·Heart Failure Clinics·Maria Rosa Costanzo
Nov 20, 2019·Current Pharmaceutical Design·Yu DongTaisheng Liang
Mar 17, 2020·American Journal of Physiology. Renal Physiology·Chuanming XuTianxin Yang
Jul 21, 2020·Journal of Cellular and Molecular Medicine·Yang PanZhi Wang

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