Abstract
Localization of apelin and its receptor APJ in limbic structures such as the hippocampus suggests potential involvement of apelin/APJ signaling in stress-related emotional responses. We have recently reported that apelin-13 exerts antidepressant-like actions in acute stressed rats, and that the hippocampus is a critical brain region mediating its actions. However, the neural mechanism underling antidepressant-like actions of apelin-13 is still largely unknown. The aim of the present study is to determine whether apelin-13 ameliorates chronic water-immersion restraint stress (CWIRS)-induced depression-like phenotypes and its neural mechanism in rats. Here, we report that CWIRS exposure leaded to upregulation of apelin/APJ signaling in the hippocampus. Apelin-13 ameliorated CWIRS-induced depression-like phenotypes including hedonic-like deficit and behavioral despairs. Moreover, apelin-13 ameliorated hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, and hippocampal BDNF expression deficit and glucocorticoid receptor (GR) nucleus translocation hypoactivity in chronic stressed rats. Finally, apelin-13-mediated effects were blocked by the selective TrkB receptor antagonist ANA-12. These results suggest that apelin-13 upregula...Continue Reading
Citations
Apr 6, 2019·Frontiers in Neuroscience·Malgorzata Halon-GolabekJedrzej Antosiewicz
May 2, 2019·Frontiers in Pharmacology·Huaiqing LuoXiaoqun Qin
Nov 14, 2019·International Journal of Molecular Sciences·Thomas Ho-Yin LeeSuk-Yu Yau
Nov 5, 2019·Frontiers in Neuroscience·Shinnosuke YasugakiYu Hayashi
Apr 2, 2020·Frontiers in Pharmacology·Shuang-Yu LvYan-Dong Wang
Aug 28, 2020·Frontiers in Genetics·Ying WangZhiying Luo
Oct 6, 2020·Frontiers in Neuroscience·Shuangyu LvXinchun Wang
Jun 25, 2019·Frontiers in Psychology·Raíssa Nóbrega de AlmeidaNicole Leite Galvão-Coelho
Sep 29, 2020·Frontiers in Pharmacology·Shuangyu LvXinchun Wang
Oct 10, 2020·Journal of Medical Biochemistry·Zekiye CatakSuleyman Aydin
Dec 15, 2020·Behavioural Brain Research·Lucas T LaudermilkRangan Maitra
Apr 22, 2020·Journal of Chemical Neuroanatomy·Li ZhouZhiyong Wang
Mar 1, 2021·Neuropeptides·Jia-Xiu ZhouShao-Wen Tian
Feb 26, 2021·Neural Plasticity·Xianquan AnYang Jin
Jun 3, 2021·International Journal of Molecular Sciences·Banseok LeeKyoung Sang Cho
Jul 22, 2021·Cancer Communications·Changqie PanWangjun Liao