Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release

Proceedings of the National Academy of Sciences of the United States of America
Nadia De MotaCatherine Llorens-Cortes

Abstract

Apelin, a recently isolated neuropeptide that is expressed in the supraoptic and the paraventricular nuclei, acts on specific receptors located on vasopressinergic neurons. The increased phasic pattern of these neurons facilitates sustained antidiuresis during dehydration or lactation. Here, we investigated whether apelin interacts with arginine vasopressin (AVP) to maintain body fluid homeostasis. We first characterized the predominant molecular forms of endogenous hypothalamic and plasma apelin as corresponding to apelin 13 and, to a lesser extent, to apelin 17. We then demonstrated that, in lactating rats, apelin was colocalized with AVP in supraoptic nucleus magnocellular neurons and given intracerebroventricularly inhibited the phasic electrical activity of AVP neurons. In lactating mice, intracerebroventricular administration of apelin 17 reduced plasma AVP levels and increased diuresis. Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis. Opposite effects o...Continue Reading

References

Apr 1, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D A PoulainR E Dyball
May 1, 1979·The Journal of Physiology·A Dutton, R E Dyball
Jan 25, 1980·Science·M J BrownsteinH Gainer
Nov 1, 1981·Neuroendocrinology·R J Bicknell, G Leng
Oct 30, 1998·Biochemical and Biophysical Research Communications·K TatemotoM Fujino
Dec 31, 1998·Journal of Neuroendocrinology·M Ludwig
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ReauxC Llorens-Cortes
Jan 5, 2000·Journal of Neurochemistry·D K LeeB F O'Dowd
Oct 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Z LenkeiC Llorens-Cortes
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
May 22, 2001·Journal of Neurochemistry·A ReauxC Llorens-Cortès
Mar 9, 2002·Biochemical and Biophysical Research Communications·Shahrad TaheriStephen Bloom
Jul 13, 2002·Neuroscience Letters·G Cristina BrailoiuNae J Dun
Aug 2, 2002·Neuroscience·A ReauxC Llorens-Cortes
Feb 13, 2003·The European Journal of Neuroscience·Marc LandryAndré Calas
Apr 2, 2003·Virology·Naiming ZhouRoger J Pomerantz
Jun 20, 2003·The European Journal of Neuroscience·Marc LandryAndré Calas

❮ Previous
Next ❯

Citations

May 7, 2008·Journal of Physiology and Biochemistry·C CarpénéI Castan-Laurell
Aug 3, 2010·Heart and Vessels·Agnieszka M KuklinskaJolanta Małyszko
Dec 1, 2006·Apoptosis : an International Journal on Programmed Cell Death·Hui XieEr-Yuan Liao
May 11, 2005·Cardiovascular Drugs and Therapy·Pasquale Pagliaro, Claudia Penna
Jul 5, 2011·Endocrine·Isabelle Castan-LaurellPhilippe Valet
Dec 29, 2004·Cardiovascular Research·Euan A AshleyThomas Quertermous
Jun 15, 2012·Journal of Environmental Monitoring : JEM·Sihem MbarekRafika Ben Chaouacha Chekir
Aug 24, 2005·Médecine sciences : M/S·Catherine Llorens-Cortès, Alain Beaudet
Mar 15, 2011·Antioxidants & Redox Signaling·Thibaut DuparcClaude Knauf
Mar 25, 2009·Journal of Hypertension·Wei-Wei LiDing-Liang Zhu
Jul 27, 2010·Acta Physiologica·M VlasovaK H Herzig
Nov 5, 2010·The Journal of Pharmacology and Experimental Therapeutics·Fanrong YaoChengwen Sun
Sep 22, 2009·American Journal of Physiology. Heart and Circulatory Physiology·David N CharoThomas Quertermous
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ahmad Y SheikhThomas Quertermous
Aug 24, 2006·Neuroendocrinology·Jennifer Altman
Jan 6, 2007·American Journal of Nephrology·Marta CodognottoGiovanni M Boffa
Sep 5, 2008·The Journal of Clinical Investigation·Hyung J ChunThomas Quertermous
Aug 15, 2013·The Journal of Endocrinology·Anne-Marie O'CarrollGeorge R Pope
Jul 7, 2009·The Journal of Endocrinology·Emma M RobertsAnne-Marie O'Carroll
Feb 15, 2008·Journal of the American Society of Nephrology : JASN·Michel AziziCatherine Llorens-Cortes
Nov 19, 2008·Internal Medicine·Zhao LiJian Hu
May 19, 2010·Biomarkers in Medicine·Jonathan R DalzellRoy S Gardner
May 14, 2010·Future Cardiology·Jonathan R Dalzell, Colette E Jackson
Mar 15, 2014·Journal of Medicinal Chemistry·Jean-François MargatheDominique Bonnet
Apr 9, 2008·European Journal of Endocrinology·Isabelle Castan-LaurellPhilippe Valet
Jun 1, 2007·Biomarkers in Medicine·Kwok S ChongTheresa A McDonagh
Sep 24, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Hua YuChao-Ke Tang
Jun 20, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Aditya PandeyJan K Rainey
Sep 17, 2014·Biomarkers in Medicine·Jonathan R DalzellRoy S Gardner
Oct 3, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nigel A ChapmanJan K Rainey
Jul 16, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A GiacobbeA Mancuso
Jun 1, 2012·Expert Opinion on Drug Discovery·Christopher J Charles
Dec 5, 2015·Blood·Frédéric AdamGeraldine Siegfried
Aug 13, 2005·The Journal of Physiology·Xiao-Hong LiuThomas E Fisher
Jan 20, 2007·The Journal of Physiology·Wenbo ZhangThomas E Fisher
Sep 10, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Vandana Jain, Aathira Ravindranath

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.