Apelin: a potential link between inflammation and cardiovascular disease in end stage renal disease patients

Scandinavian Journal of Clinical and Laboratory Investigation
Amal M El-ShehabyAmin R Roshdy

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients. Increasing evidence suggests a role for apelin in the pathology of the cardiovascular system. In the present study, the plasma level of apelin was studied in patients with hemodialysis to assess the effect of renal transplantation and dialysis session on plasma apelin and whether circulating apelin levels reflect cardiovascular homeostasis and inflammation in these patients. Plasma apelin, high sensitive CRP (hsCRP) and IL-6 levels were investigated in 30 end stage renal disease (ESRD) patients on maintenance hemodialysis (HD), a group of 15 HD patients scheduled for renal transplantation and a group of 15 HD patients on maintenance HD, as well as ten healthy volunteer subjects who served as controls. An echocardiography was performed for all subjects. Plasma apelin levels were significantly lower in hemodialyzed patients compared to controls. Plasma apelin was also found to be positively correlated with left ventricular end systolic dimension (LVESD), left ventricular end diastolic dimension (LVEDD), interventricular septum (IVS), right ventricle (RV), left atrium (LA), Aorta (Ao), while, it was negatively correlated with hsCRP and...Continue Reading

References

May 1, 1996·Kidney International·P S ParfreyP E Barre
Sep 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·H RakowskiC Tomlinson
Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M J Sarnak, A S Levey
Aug 30, 2000·Lancet·C BaigentD Wheeler
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·J Craig LongeneckerMichael J Klag
Sep 7, 2002·Circulation Research·István SzokodiHeikki Ruskoaho
Oct 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshio IwashimaYuhei Kawano
Dec 6, 2002·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliPietro Finocchiaro
Jun 10, 2003·Nutritional Neuroscience·Marie O'SheaMargaret J Morris
Aug 14, 2003·Biochemical and Biophysical Research Communications·Gábor FöldesMiklós Tóth
Sep 10, 2003·Circulation·Mary M ChenThomas Quertermous
Sep 15, 2004·Circulation·Mark F BerryY Joseph Woo
Sep 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard MasriYves Audigier
Oct 2, 2004·Kidney International·Walter H HörlCheryl J Zusman
Dec 29, 2004·Cardiovascular Research·Euan A AshleyThomas Quertermous
Jan 29, 2005·Endocrinology·Jérémie BoucherPhilippe Valet
May 24, 2005·Pharmacology & Therapeutics·Matthias J Kleinz, Anthony P Davenport
Sep 27, 2005·Transplantation Proceedings·D MontanaroG Mioni
Nov 3, 2005·Regulatory Peptides·Jens Peter GoetzeLennart Friis-Hansen
Mar 22, 2006·American Journal of Nephrology·Jolanta MałyszkoMichał Myśliwiec
Mar 25, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Tatsuo HashimotoSatoshi Umemura
May 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Danièle DaviaudIsabelle Castan-Laurell
Aug 8, 2006·European Journal of Heart Failure·Pietro FranciaMassimo Volpe
Oct 24, 2006·European Journal of Pharmacology·Tieying DaiWei Dong Gao
Jan 6, 2007·American Journal of Nephrology·Marta CodognottoGiovanni M Boffa
Feb 24, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bogdan GurzuGheorghe Petrescu
Oct 11, 2008·Atherosclerosis·Ilker TasciAlper Sonmez
Mar 24, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas J LeeperThomas Quertermous

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Citations

Sep 24, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Hua YuChao-Ke Tang
Jun 16, 2012·Blood Purification·Valeria CernaroMichele Buemi
Jun 2, 2012·Cardiology Research and Practice·Seyyed M R Kazemi-BajestaniGavin Y Oudit
Jan 11, 2013·American Journal of Physiology. Renal Physiology·Robert T DayDenis Feliers
Mar 6, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shifang HuangLanfang Li
Oct 19, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Derya KocerIsmail Kocyigit
Mar 16, 2012·Renal Failure·Viviane O LealDenise Mafra
Jul 16, 2014·Renal Failure·Sevgi YavuzAysun Karabay Bayazıt
Dec 6, 2011·Pulmonary Circulation·Charlotte U AndersenU Simonsen
Sep 29, 2015·Korean Circulation Journal·Mehmet Zihni BilikSait Alan
Jun 30, 2019·Journal of Cellular Physiology·Huaiqing LuoJin Xu
Aug 11, 2017·Journal of Cellular Physiology·Zhen HuangLinxi Chen
Sep 10, 2020·Journal of Cellular Physiology·Mitrasadat RezaeiRamin Pouriran
Feb 9, 2017·Frontiers in Molecular Neuroscience·Yili WuBo Bai
Dec 26, 2016·Obesity Surgery·Elias KhajehMohammad Javad Hosseinzadeh-Attar
Sep 6, 2018·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Sahar Vahdat
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yuichiro SumiShuichi Tsuruoka
Jul 12, 2020·Scientific Reports·Hasmik SoloyanSargis Sedrakyan
Nov 23, 2020·Nigerian Journal of Clinical Practice·R BentliA Dogan
Sep 1, 2021·Archives of Biochemistry and Biophysics·Yurong WangHui Fang

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