Apelin protects against acute renal injury by inhibiting TGF-β1

Biochimica Et Biophysica Acta
Hong ChenKun Huang

Abstract

Renal ischemia/reperfusion (I/R) injury is the most common cause of acute kidney injury, having a high rate of mortality and no effective therapy currently available. Apelin-13, a bioactive peptide, has been shown to inhibit the early lesions of diabetic nephropathy in several mouse models by us and others. To test whether apelin-13 protects against renal I/R induced injury, male rats were exposed to renal I/R injury with or without apelin-13 treatment for 3 days. Apelin-13 treatment markedly reduced the injury-induced tubular lesions, renal cell apoptosis, and normalized the injury induced renal dysfunction. Apelin-13 treatment inhibited the injury-induced elevation of inflammatory factors and Tgf-β1, as well as apoptosis. Apelin-13 treatment also inhibited the injury-induced elevation of histone methylation and Kmt2d, a histone methyltransferase of H3K4me2, following renal I/R injury. Furthermore, in cultured renal mesangial and tubular cells, apelin-13 suppressed the injury-induced elevation of Tgf-β1, apoptosis, H3K4me2 and Kmt2d under the in vitro hypoxia/reperfusion (H/R) conditions. Consistently, over-expression of apelin significantly inhibited H/R-induced elevation of TGF-β1, apoptosis, H3K4me2 and Kmt2d. The present s...Continue Reading

References

Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Oct 30, 1998·Biochemical and Biophysical Research Communications·K TatemotoM Fujino
Dec 16, 1998·Kidney International·R A Star
Mar 16, 2000·The EMBO Journal·T Kouzarides
May 22, 2001·Journal of Neurochemistry·A ReauxC Llorens-Cortès
Feb 1, 2002·The New England Journal of Medicine·Helmut SchifflRainald Fischer
Aug 2, 2002·Neuroscience·A ReauxC Llorens-Cortes
Apr 5, 2003·Kidney International·Suroj SupavekinPrasad Devarajan
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre, Joel M Weinberg
Sep 10, 2003·Circulation·Mary M ChenThomas Quertermous
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Kengo FuruichiHitoshi Yokoyama
Jul 16, 2004·Kidney International·Faikah GuelerHermann Haller
Sep 2, 2005·Journal of the American Society of Nephrology : JASN·Claudia PetryJosef Pfeilschifter
Jun 24, 2006·Chemistry & Biology·Min Gyu LeeRamin Shiekhattar
Aug 19, 2007·Regulatory Peptides·Jiu-Chang ZhongXi-Yong Yu
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Takeshi MarumoToshiro Fujita
Dec 3, 2008·Cell Metabolism·Cédric DrayPhilippe Valet
Oct 16, 2009·Cardiology in Review·Robin QuaziWilliam H Frishman
Oct 23, 2009·Annals of the New York Academy of Sciences·Volker H Haase
Apr 3, 2010·Journal of the American Society of Nephrology : JASN·Hsiao-Fen LiRuey-Bing Yang
Oct 20, 2010·American Journal of Nephrology·K J Kelly, Jesus H Dominguez
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Feb 1, 2012·Archives of Medical Science : AMS·Cabir AlanAhmet Resit Ersay
Jul 28, 2012·Seminars in Nephrology·Mary E ChoiSung Il Kim
Sep 13, 2012·Experimental and Therapeutic Medicine·Tamer SagirogluSerhat Oguz
Dec 15, 2012·The Journal of Biological Chemistry·Ji-An PanWei-Xing Zong
Jan 11, 2013·American Journal of Physiology. Renal Physiology·Robert T DayDenis Feliers
May 11, 2013·Journal of Biosciences·F MolinaM L Del Moral
Oct 17, 2013·Biochemical and Biophysical Research Communications·Paveenarat AukkarasongsupKeiji Moriyama
Nov 2, 2013·The Journal of Clinical Investigation·Teruki SatoKeiji Kuba

❮ Previous
Next ❯

Citations

Oct 19, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Derya KocerIsmail Kocyigit
Nov 5, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yue SunLing Zheng
Apr 14, 2017·Acta Biochimica Et Biophysica Sinica·Jiaqi LiuLinxi Chen
Dec 6, 2018·The Journal of Physiology·Hong ChenKun Huang
Jun 7, 2017·Journal of the American Society of Nephrology : JASN·Hong ChenKun Huang
Aug 11, 2017·Journal of Cellular Physiology·Zhen HuangLinxi Chen
Apr 2, 2016·International Journal of Molecular Medicine·Qun ZhouLinxi Chen
Sep 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanting Chen, Chuanming Xu
Dec 15, 2018·Physiological Reports·Tilman MüllerDaniel Batlle
Jul 25, 2019·Scientific Reports·Claire VinelColette Denis
Jul 12, 2020·Scientific Reports·Hasmik SoloyanSargis Sedrakyan
Oct 11, 2017·Journal of Molecular Cell Biology·Danyang WanLing Zheng
Jan 11, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuanyuan LiuHongjun Shi
Jun 19, 2019·Current Medical Science·Chao WangKun Huang
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xiaobo ZhangBingru Fei
Mar 14, 2017·Cell and Tissue Research·Nicola Wanner, Wibke Bechtel-Walz
May 26, 2020·Biochemical and Biophysical Research Communications·Nisha SharmaAnil Bhanudas Gaikwad
Jul 13, 2019·Life Sciences·Mohammad Kazemi ArababadiGholamreza Asadikaram
Apr 18, 2021·The Journal of Sexual Medicine·Mikael SturnyNikolaos Stergiopulos
Oct 31, 2019·The Journal of Surgical Research·Firouzeh GholampourSeyed Mohammad Owji
Aug 15, 2021·Nature Reviews. Nephrology·Fiona A ChapmanNeeraj Dhaun
Sep 14, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liangli JinZhi Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

© 2022 Meta ULC. All rights reserved