APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas

Journal of Clinical Medicine
Ji-Myung KimKyung-Hee Kim

Abstract

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cell renal cell carcinoma (ccRCC), hepatocellular carcinoma (HCC), and proximal and distal cholangiocarcinoma (CC). A total of 216 frozen serum samples were collected from 39 healthy control cases, 32 patients with ≥58 copies/mL of hepatitis B viral DNA (HBV DNA (+)), 40 ccRCC cases, 59 HCC cases, and 46 CC cases. The serum samples were examined for s-APEX1 concentration by enzyme-linked immunosorbent assay. The association of APEX1 expression with clinicopathological characteristics was also studied by immunohistochemical staining in 106 ccRCC, 131 HCC, and 32 intrahepatic CC cases. The median s-APEX1 concentrations of the HCC, CC, ccRCC, healthy control, and HBV DNA (+) groups were 0.294, 0.710, 0.474, 0.038, and 2.384 ng/mL, respectively (p < 0.001). Univariate and multivariate analyses revealed that increased cytoplasmic APEX1 expression led to a shorter disease-free survival period in HCC and CC cases. We suggest...Continue Reading

References

Feb 12, 2005·Antioxidants & Redox Signaling·Gianluca TellMark R Kelley
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ann M O'HaraSheila E Crowe
Oct 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hye-Mi LeeEun-Kyeong Jo
May 15, 2013·Biochemical and Biophysical Research Communications·Sunga ChoiByeong Hwa Jeon
Jul 16, 2014·International Journal of Molecular Sciences·Tsung-Lin ChengJui-Hsiang Hung
Feb 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ju Hyun ShinByeong Hwa Jeon
May 10, 2015·Nucleic Acids Research·Arianna BarchiesiCarlo Vascotto
Jan 29, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robin Kit-Ho LaiCarmen Chak-Lui Wong
May 28, 2016·Chonnam Medical Journal·Sunga ChoiByeong Hwa Jeon
Aug 3, 2018·Journal of Gastroenterology and Hepatology·Hyuk Soo EunKyung-Hee Kim
Apr 16, 2019·Expert Review of Molecular Diagnostics·Giuseppe LucarelliMichele Battaglia

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Citations

Aug 11, 2020·World Journal of Clinical Cases·Ru ZhengHua-Jie Cai
Jan 28, 2021·Archives of Gynecology and Obstetrics·Aili TanPengxing Sun

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Methods Mentioned

BETA
GTPase
surgical resection
Enzyme-Linked
enzyme-linked immunosorbent assay
PCR
ELISA

Software Mentioned

SPSS

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