Apheresis affects bone and mineral metabolism

Bone
Karin AmreinHarald Dobnig

Abstract

Apheresis is a procedure to selectively obtain blood components. For the collection process citrate is routinely used. It inhibits coagulation by binding to ionized calcium and leads to metabolic alkalosis. Whether regular apheresis affects bone and mineral metabolism is unknown. The intention of this study was to investigate 1) the acute effects of apheresis on acid-base balance, bone and mineral metabolism and 2) to compare bone mineral density (BMD) at the lumbar spine and hip of donors to matched control subjects. In this open, observational, single-center, cross-sectional study we enrolled 102 regular plasma and thrombocyte donors to pursue objective 1) and compared those to 102 matched controls (CTR) for objective 2). Platelet donation led to significant decreases in serum ionized calcium (-17%) and phosphate (-18%), to marked increases in base excess (57%) and PTH levels (192%) during apheresis. Baseline biochemical comparisons between donors and CTR revealed significantly lower values for donors for serum calcium, albumin, and 25-hydroxyvitamin D levels. Mean Z-score at the lumbar spine adjusted for BMI, average physical activity and daily calcium intake was lower for donors (-0.28+/-0.11) when compared to CTR subjects ...Continue Reading

References

Jan 1, 1984·Journal of Clinical Apheresis·R G Strauss
Jan 1, 1994·Journal of Clinical Apheresis·R G Strauss
Jan 1, 1993·Journal of Clinical Apheresis·I KobayashiA Ueno
Oct 12, 2002·Transfusion·Stefan J LaspinaWilliam G Murphy
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May 26, 2007·Transfusion·Thomas B Wiltbank, Gerald F Giordano
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Citations

May 27, 2015·Journal of Clinical Apheresis·Josef Evers, Uwe Taborski
Oct 15, 2011·Blood Reviews·Karin AmreinCamilla Drexler
Nov 27, 2015·Journal of Clinical Apheresis·Walter BialkowskiPaula Papanek
Nov 6, 2013·Transfusion·Steven KleinmanUNKNOWN National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Jun 3, 2015·Vox Sanguinis·C L BootP Lips
Apr 25, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ying ChenMarkus Dettke
Nov 20, 2016·Transfusion·Katrine GrauUNKNOWN National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

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