Apheresis and transplant of hematopoietic progenitor cells (HPC) from allogeneic donors of age above 60 years

Bone Marrow Transplantation
W E JanssenH F Fernandez

Abstract

Over the immediate past 4 years, our program has collected hematopoietic progenitor cells by apheresis from 48 individuals aged 61 and over (range 61-71 years of age). We have retrospectively analyzed the collection and transplant results associated with employing these donors, and have compared them with 175 donors aged 60 or less who were collected during the same time period. We have found no significant difference in venous access (P = 0.208), rate of post-transplant engraftment of neutrophils (P = 0.117) and platelets (P = 0.692), or in rate and grade of acute GVHD (P = 0.806). However, we have found that these older donors have a significantly lower mobilization of CD34 + cells as reflected in lower absolute counts of circulating CD34 + cells pre-apheresis (P = 0.016). This, in turn, results in lower CD34 + cell yields in apheresis products (P < 0.001), trending towards requiring more apheresis procedures (22.9 vs 13.7%, P = 0.095) to collect sufficient CD34 + cells for transplantation. We conclude that it is practical when necessary to employ donors aged 60 and above, as well as safe for both donor and intended recipient. However, concern over reduced CD34 + cell mobilization may be sufficient grounds to seek younger don...Continue Reading

References

May 23, 1998·Journal of Hematotherapy·G MartiS Serke
Mar 16, 2002·Bone Marrow Transplantation·L L Popplewell, S J Forman
Oct 22, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Carolyn Katovich HurleyDennis L Confer
Sep 6, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert A BrayDennis L Confer
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elie RichaAndrew Artz

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Citations

Feb 13, 2019·Transfusion·Jian ChenMelissa S Pessin
Apr 16, 2020·Advanced Biosystems·Kinga MatułaWilhelm T S Huck

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