Apheresis to Mitigate Atherosclerotic Vascular Disease

American Journal of Hypertension
Bruce S Sachais, Beth H Shaz

Abstract

Therapeutic apheresis is a term used to describe a group of treatments where blood components are separated in real time, and one component is removed, exchanged, and/or treated to remove pathogenic substances from the circulation. Plasma exchange, which removed all plasma components, and lipid apheresis which selectively removes lipoproteins from circulation, have both been used to treat atherosclerotic vascular diseases. To review the literature regarding the application of therapeutic apheresis for atherosclerotic vascular diseases. Primarily lipid apheresis is used to treat atherosclerotic vascular diseases, particularly familial hypercholesterolemia, lipoprotein (a) hyperlipoproteinemia and peripheral vascular diseases. Lipid apheresis can be used as first line or second line treatment with a strong evidenced-based recommendation. Its use has decreased atherosclerotic events. Lipid apheresis is an important therapy for the treatment of familial hypercholesterolemia, lipoprotein (a) hyperlipoproteinemia and peripheral vascular diseases. Lipid apheresis does more than remove low-density lipoproteins and other lipoproteins but also decreases inflammatory markers and improves blood flow.

References

Apr 4, 1986·Science·M S Brown, J L Goldstein
Apr 5, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Werner O RichterJens Klinkmann
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Mar 21, 2006·Atherosclerosis·Jeff Thompsen, Paul D Thompson
Apr 21, 2006·Cardiovascular Research·Elaine Paffen, Moniek P M DeMaat
Sep 29, 2007·Blood Purification·A RamunniP Coratelli
Jul 23, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
May 5, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Michael J KoziolekGerhard A Müller
Apr 5, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kouichi TamuraSatoshi Umemura
Jul 22, 2014·Journal of Clinical Apheresis·Ahmed SheriffMartin Möckel
May 26, 2015·Current Atherosclerosis Reports·Vijay G Bhoj, Bruce S Sachais
May 27, 2015·Journal of Clinical Apheresis·Jean-Philippe Drouin-ChartierPatrick Couture
Jul 2, 2015·Journal of Clinical Apheresis·Isaac EliazPatrick M Moriarty
Jan 19, 2016·Current Opinion in Lipidology·Patrick M Moriarty
Feb 25, 2017·Blood·Christian Schulz, Steffen Massberg

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Citations

Jan 7, 2019·Pathology·Elisa Waldmann, Klaus G Parhofer

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