PMID: 589914Nov 1, 1977

Aphthoid ulcers in Crohn's colitis

Clinical Radiology
K C Simpkins

Abstract

Aphthoid ulceration is a strong indication and the earliest radiographic sign of Crohn's colitis. These small discrete ulcers were found by double contrast barium enema examination in 40 out of 91 patients with Crohn's colitis. Seen en face each ulcer appears as a central fleck of barium surrounded by a translucent halo set amidst a patch of normal mucosa. Their detection gives a more accurate assessment of the extent of disease. This information is required in order to plan medical or surgical treatment and can only be provided by meticulous double contrast examination or colonoscopy. Aphthoid ulceration has been demonstrated prior to the onset of bowel symptoms, and several years before the advent of severe colonic disease. The appearance of aphthoid ulcers in established quiescent disease has been observed to herald a relapse. The radiographic demonstration of the evolution of ulceration, which is illustrated, closely reflects what is seen on macroscopic examination of excised specimens and explains the characteristic patchiness and discontinuity of disease.

References

Aug 1, 1976·Gut·A G MorganE G Tinsley
Jan 1, 1976·Gastrointestinal Radiology·I Laufer
Aug 1, 1975·Gastrointestinal Endoscopy·K Geboes, G Vantrappen
Jan 1, 1976·Clinical Radiology·G M Fraser, J M Findlay
Nov 1, 1973·The American Journal of Digestive Diseases·G E SmithJ L Pitcher
Mar 14, 1970·Lancet·A C Dean, D J Shearman
Feb 1, 1973·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R R WarwickD J Shearman
Oct 1, 1972·The British Journal of Surgery·K C Simpkins
Feb 1, 1966·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·A Weinfeld
Jul 1, 1970·Gut·F BRAHME, A Wenckert
Dec 1, 1965·Gut·B K GrayB C Morson
May 4, 1967·The New England Journal of Medicine·T M BaylessT R Hendrix
Jun 20, 1953·Lancet·B N BROOKE
Apr 1, 1961·Acta Radiologica·S WELIN, F BRAHME

Citations

Jan 1, 1984·Gastrointestinal Radiology·H R Degryse, A M De Schepper
Jan 1, 1985·Gastrointestinal Radiology·A V TielbeekC Boetes
Aug 1, 1992·Clinical Radiology·J C HealyP J Kumar
Sep 1, 1978·Australasian Radiology·D Paterson
Feb 1, 1996·Journal of Gastroenterology and Hepatology·V JayanthiJ F Mayberry
Mar 14, 2000·Radiology·M TaruishiY Kohgo
Mar 29, 2001·The British Journal of Radiology·T MatsumotoM Fujishima
Jun 1, 1985·The British Journal of Radiology·D B Downey, R A Nakielny
Jan 1, 1980·Scandinavian Journal of Gastroenterology·S S PoulsenS Jarnum
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·C I Bartram

Related Concepts

Barium Sulfate (2: 1)
Colonic Diseases
IIeocolitis
Ulcer

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