Apical control of conidiation in Aspergillus nidulans

Current Genetics
Elixabet Oiartzabal-AranoOier Etxebeste

Abstract

The infection cycle of filamentous fungi consists of two main stages: invasion (growth) and dispersion (development). After the deposition of a spore on a host, germination, polar extension and branching of vegetative cells called hyphae allow a fast and efficient invasion. Under suboptimal conditions, genetic reprogramming of hyphae results in the generation of asexual spores, allowing dissemination to new hosts and the beginning of a new infection cycle. In the model filamentous fungus Aspergillus nidulans, asexual development or conidiation is induced by the upstream developmental activation (UDA) pathway. UDA proteins transduce signals from the tip, the polarity site of hyphae, to nuclei, where developmental programs are transcriptionally activated. The present review summarizes the current knowledge on this tip-to-nucleus communication mechanism, emphasizing its dependence on hyphal polarity. Future approaches to the topic will also be suggested, as stimulating elements contributing to the understanding of how apical signals are coupled with the transcriptional control of development and pathogenesis in filamentous fungi.

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Citations

Jul 2, 2016·Scientific Reports·Mi-Kyung LeeJae-Hyuk Yu
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Oier Etxebeste, Eduardo A Espeso
Jul 29, 2016·G3 : Genes - Genomes - Genetics·Ariane BraultSimon Labbé
May 9, 2019·Cellular and Molecular Life Sciences : CMLS·Ainara OtamendiOier Etxebeste
Aug 26, 2017·Current Genetics·Özlem Sarikaya BayramÖzgür Bayram

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