PMID: 11336670May 5, 2001Paper

Apical localization of wingless transcripts is required for wingless signaling

Cell
A J SimmondsHenry M Krause

Abstract

Many developing and adult tissues are comprised of polarized epithelia. Proteins that are asymmetrically distributed in these cells are thought to be localized by protein trafficking. Here we show that the distribution and function of the signaling protein Wingless is predetermined by the subcellular localization of its mRNA. High-resolution in situ hybridization reveals apical transcript localization in the majority of tissues examined. This localization is mediated by two independently acting elements in the 3' UTR. Replacement of these elements with non- or basolaterally localizing elements yields proteins with altered intracellular and extracellular distributions and reduced signaling activities. This novel aspect of the wingless signaling pathway is conserved and may prove to be a mechanism used commonly for establishing epithelial cell polarity.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R GangulyR Krishnan
Jul 30, 1992·Nature·A Ephrussi, R Lehmann
Aug 1, 1991·Mechanisms of Development·F GonzálezA Martinez Arias
Jan 1, 1989·Annual Review of Cell Biology·J H Fessler, L I Fessler
Oct 22, 1982·Science·G M Rubin, A C Spradling
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J J Lin
Feb 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D GullbergJ H Fessler
Aug 1, 1995·Developmental Biology·K B YoffeN Perrimon
May 1, 1995·Genes & Development·S YanagawaR Nusse
Jan 1, 1993·Journal of Cell Science. Supplement·D F Woods, P J Bryant
May 1, 1996·BioTechniques·S C HughesH M Krause
Jan 1, 1996·Annual Review of Cell and Developmental Biology·W J BrookS M Cohen
Mar 24, 1997·The Journal of Cell Biology·E H KislauskisR H Singer
Jun 5, 1997·Nature·K Simons, E Ikonen
Mar 24, 1998·Mechanisms of Development·J Dubowy, P M Macdonald
Oct 6, 1998·Annual Review of Biochemistry·A BashirullahH D Lipshitz
Dec 4, 1998·Seminars in Cell & Developmental Biology·E Ikonen, K Simons
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
Jan 29, 1999·Physiological Reviews·C YeamanW J Nelson
Aug 12, 1999·Seminars in Cell & Developmental Biology·M Strigini, S M Cohen
Apr 4, 2000·Current Biology : CB·M Strigini, S M Cohen
May 20, 2000·Current Opinion in Cell Biology·J L Christian

❮ Previous
Next ❯

Citations

Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S H Myster, M Peifer
Jul 13, 2002·The Journal of Experimental Zoology·Michael Patrick Wilkie
Jul 4, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jesús EspadaVanessa Medina
Aug 14, 2003·Experimental Cell Research·Arlene R Wechezak, Daniel E Coan
Nov 26, 2002·Trends in Genetics : TIG·Hildegard Tekotte, Ilan Davis
Jul 20, 2002·Seminars in Cell & Developmental Biology·Kenneth M Cadigan
Apr 4, 2002·Traffic·Eugeni V Entchev, Marcos A González-Gaitán
Dec 15, 2010·Nucleic Acids Research·Patrick C GilliganKaruna Sampath
Aug 24, 2012·Journal of the Royal Society, Interface·James EberwineJunhyong Kim
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I M Palacios, D St Johnston
Aug 23, 2012·Development·Caroline MedioniFlorence Besse
Jan 23, 2008·PLoS Genetics·Sally Horne-Badovinac, David Bilder
Apr 19, 2005·Genetics·Sabrina C DesbordesBénédicte Sanson
Aug 23, 2012·F1000 Biology Reports·Graydon B Gonsalvez, Roy M Long
Dec 3, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jialong LiangZhongsheng Sun
Aug 27, 2004·Médecine sciences : M/S·Eugenia BasyukEdouard Bertrand
Jan 17, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Justinn BarrPaul Schedl
Apr 3, 2007·Seminars in Cell & Developmental Biology·Tung-Gia DuRalf-Peter Jansen
May 8, 2009·Molecular Reproduction and Development·Malgorzata Kloc
Mar 15, 2016·Nature Cell Biology·Yasuo YamazakiJean-Paul Vincent
Mar 20, 2014·Wiley Interdisciplinary Reviews. RNA·Xianying A Cui, Alexander F Palazzo
May 18, 2004·Current Opinion in Cell Biology·Veronique Van de Bor, Ilan Davis
May 14, 2014·Developmental Biology·Tirthadipa Pradhan-Sundd, Esther M Verheyen
Nov 9, 2001·Annual Review of Genetics·U TepassR Fehon
Dec 20, 2005·Current Biology : CB·Alexander F Schier
Jun 14, 2002·Current Biology : CB·Sven PfeifferJean-Paul Vincent
Feb 2, 2013·Developmental Cell·David W LernerSally Horne-Badovinac
Nov 15, 2002·Developmental Cell·Jean-Paul Vincent, Laurence Dubois
Jul 5, 2005·Developmental Cell·Véronique Van De BorIlan Davis
Jan 29, 2013·Biochimica Et Biophysica Acta·Orit Hermesh, Ralf-Peter Jansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.