PMID: 25738871Mar 5, 2015Paper

Apigenin and Breast Cancers: From Chemistry to Medicine

Anti-cancer Agents in Medicinal Chemistry
S M NabaviSeyed Fazel Nabavi

Abstract

Breast cancer is one of the most common causes of the death among women worldwide. Metabolic disorders, alcohol consumption, hormone replacement therapy, genetic susceptibility and not having children are well known risk factors for breast cancer. Surgical resection, radiation therapy, and chemotherapy are among the limited treatment options for breast cancer. Thus, there is growing need to find new chemopreventive agents that may be effective in prevention and/or management of breast cancer. Natural products such as flavonoids provide a variety of anticancer compounds which can be useful for prevention or treatment of breast cancer. The usefulness of dietary phytochemicals in the prevention of this disease is supported by a plethora of experimental and epidemiological studies. Apigenin, a well-known flavone, is found in several dietary plant foods such as parsley, celery, thyme, celeriac, chamomile, onions, lemon balm, and oranges. Extensive studies have shown that apigenin have potent antioxidant, anti-inflammatory, and anticarcinogenic properties. The aim of the present communication is to establish the therapeutic potential of apigenin against breast cancer through critical analysis of data from 5 in vitro and in vivo studi...Continue Reading

Citations

Oct 13, 2015·Life Sciences·Kasi Pandima DeviSeyed Mohammad Nabavi
Jul 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eric Hesse
Feb 14, 2017·Oxidative Medicine and Cellular Longevity·Raquel P SouzaMarcia E L Consolaro
Oct 5, 2017·International Journal of Environmental Research and Public Health·Hyeri JeongYoungjun Kim
Jan 14, 2016·Applied Biochemistry and Biotechnology·Tariq KhanZabta Khan Shinwari
Jun 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karel ŠmejkalMilan Žemlička
Nov 6, 2015·Journal of Experimental & Clinical Cancer Research : CR·Haiyan LiXiujie Wang
Jun 2, 2017·Experimental and Therapeutic Medicine·Kun ZhangXing Jin
Mar 16, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Ivana Vrhovac MadunićGoran Gajski
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Darija Šarić MustapićMirza Bojić
Dec 18, 2020·Life Sciences·Semim Akhtar AhmedAjaikumar B Kunnumakkara
Mar 16, 2021·Frontiers in Pharmacology·Xinyi MaDingsheng Lin
Jul 6, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Haruna NagayoshiTsutomu Shimada

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