Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

Frontiers in Chemistry
Milad AshrafizadehHamed Mirzaei

Abstract

Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cancer cells, and minimize their migration. Besides, these treatments are associated with adverse effects on normal cells and organs. These therapies are not able to increase the overall survival rate of patients; hence, finding novel adjuvants or alternatives is so essential. Up to now, medicinal herbs were utilized for therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, were employed for cancer treatment. Of them, apigenin, as a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory and anti-oxidant effects), has shown substantial anticancer activity. It seems that apigenin is capable of suppressing the proliferation of cancer cells via the induction of cell cycle arrest and apoptosis. Besides, apigenin inhibits metastasis via down-regulation of matrix metalloproteinases and the Akt signaling pathway. In pancreatic cancer cells, apigenin sensitizes cells in chemotherapy, and affects molecular pathways such as the ...Continue Reading

References

Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Schatzkin, G Kelloff
Feb 1, 1994·European Journal of Biochemistry·M Mueckler
Jun 1, 1997·Journal of Pharmaceutical Sciences·B LiD F Birt
Mar 18, 2000·The Journal of Nutrition·K Singletary
Dec 30, 2000·The Journal of Biological Chemistry·C ChenA Maity
Jan 15, 2002·Virchows Archiv : an International Journal of Pathology·P S MooreA Scarpa
Mar 20, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yan Liu, Ming Hu
Aug 1, 2002·Oncogene·Padmalatha Channavajhala, David C Seldin
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jun ChenMing Hu
Jun 16, 2004·CA: a Cancer Journal for Clinicians·Anne S TsaoWaun Ki Hong
Oct 7, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Angéline GradolattoMarie-Chantal Canivenc-Lavier
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susanna C LarssonAlicja Wolk
Aug 22, 2006·Experimental and Molecular Pathology·Anshu AgrawalDevendra K Agrawal
Aug 23, 2006·ANZ Journal of Surgery·Giuseppe GarceaDavid P Berry
Aug 31, 2006·Molecular Cancer Research : MCR·Giovanni Melillo
Jan 2, 2007·Molecular Cancer·Michael B UjikiThomas E Adrian
Mar 3, 2007·Histology and Histopathology·N J Mabjeesh, S Amir
Jun 15, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lili WanChunlin Chen
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Mar 18, 2008·Free Radical Biology & Medicine·Sanjeev Shukla, Sanjay Gupta
Jul 3, 2008·Molecular and Cellular Biochemistry·David C SeldinIsabel Dominguez
May 12, 2009·Journal of Clinical Biochemistry and Nutrition·Eun Jeong Choi, Gun-Hee Kim
Jan 22, 2010·Cancer Causes & Control : CCC·Jerry PoleselCarlo La Vecchia
Mar 23, 2010·Pharmaceutical Research·Sanjeev Shukla, Sanjay Gupta
Dec 21, 2010·Phytotherapy Research : PTR·Sandra FreitasIvana Nascimento
Jan 6, 2011·Molecular Nutrition & Food Research·Jodee Johnson, Elvira Gonzalez de Mejia
Jan 14, 2011·The Journal of Surgical Research·Laleh G MelstromDavid J Bentrem
Jan 1, 2010·Cell Death & Disease·R R Ruela-de-SousaM P Peppelenbosch

❮ Previous
Next ❯

Citations

Apr 3, 2021·Cancer Cell International·Zeeshan JavedJavad Sharifi-Rad
Jun 3, 2021·Cancers·Karin Jöhrer, Serhat Sezai Ҫiҫek
Jul 11, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiGautam Sethi
Oct 31, 2021·Cancer Cell International·Zahra NozhatAmirhossein Ahmadi

❮ Previous
Next ❯

Methods Mentioned

BETA
Transmission electron microscopy
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT00609310

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.