Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation

FEBS Letters
Ichiro KawasakiYhong-Hee Shim

Abstract

Treatment of Caenorhabditis elegans with apigenin, 5,7,4'-trihydroxyflavone, induces larval growth inhibition. To understand the molecular basis of apigenin-induced larval growth inhibition, the effects of apigenin on DAF-16 activity were examined. DAF-16 was activated through nuclear translocation and the mRNA level of sod-3, one of the known DAF-16 target genes, was increased upon apigenin treatment. DAF-16 activity was required for the growth inhibition, since the larval growth retardation upon apigenin treatment was suppressed in daf-16 mutants. These results indicate that apigenin acts as a stressor that activates DAF-16, which in turn inhibits larval growth.

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Citations

Mar 27, 2013·Parasitology Research·Ajay Kumar Rana, Shailja Misra-Bhattacharya
Jun 2, 2012·Journal of Agricultural and Food Chemistry·Susana González-ManzanoCelestino Santos-Buelga
May 21, 2011·The American Journal of Chinese Medicine·Su-Jin KimSeung-Heon Hong
Oct 15, 2013·BioFactors·Juewon KimTae Ryong Lee
Jun 6, 2013·International Journal of Molecular Sciences·Christian BüchterWim Wätjen
Jan 18, 2020·International Journal of Molecular Sciences·Xueyan YangRui Hai Liu
Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Néstor RomeroÁngel Céspedes
Aug 15, 2021·Ageing Research Reviews·Mohankumar AmirthalingamShinkichi Tawata

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