Apixaban versus Warfarin for the Prevention of Periprocedural Cerebral Thromboembolism in Atrial Fibrillation Ablation: Multicenter Prospective Randomized Study

Journal of Cardiovascular Electrophysiology
Taishi KuwaharaAtsushi Takahashi

Abstract

Stroke can be a life-threatening complication of atrial fibrillation (AF) catheter ablation. Uninterrupted warfarin treatment contributes to minimizing the risk of stroke complications. This was a prospective, open-label, randomized, multicenter study assessing the safety and efficacy of apixaban for the prevention of cerebral thromboembolism complicating AF catheter ablation. Two hundred patients with drug-resistant AF were equally assigned to take either apixaban (5 mg or 2.5 mg twice daily) or warfarin (target international normalized ratio, 2-3) for at least 1 month before AF ablation. Neither drug regimen was interrupted throughout the operative period. Diffusion-weighted magnetic resonance imaging was performed for all patients to detect silent cerebral infarction (SCI) after the ablation. Primary outcomes were defined as the occurrence of stroke, transient ischemic attack, SCI, or major bleeding that required intervention. The secondary outcome was minor bleeding. The groups did not statistically differ in patients' backgrounds or procedural parameters. During AF ablation, the apixaban group required administration of more heparin to maintain an activated clotting time > 300 seconds than the warfarin group (apixaban, 14,...Continue Reading

References

Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Oct 4, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nirmala RaghavanDonglu Zhang
May 9, 2009·Journal of the American College of Cardiology·Riccardo CappatoAllan Skanes
Nov 26, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan Wilko SchrickelTorsten Sommer
Dec 10, 2009·Circulation. Arrhythmia and Electrophysiology·Riccardo CappatoElia Biganzoli
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jan 25, 2012·Circulation. Arrhythmia and Electrophysiology·Pasquale SantangeliAndrea Natale
Apr 13, 2013·Journal of Cardiovascular Electrophysiology·William MaddoxH Thomas McElderry
Jul 25, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Benjamin A SteinbergJonathan P Piccini
Aug 21, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Stefan H Hohnloser, A John Camm
Aug 21, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Aref A Bin AbdulhakAlan P Wimmer
Feb 12, 2014·The American Journal of Cardiology·Partha SardarWilbert S Aronow
Dec 10, 2014·Pacing and Clinical Electrophysiology : PACE·Tomoyuki NagaoToyoaki Murohara
Apr 18, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tomoyuki NagaoToyoaki Murohara
Apr 22, 2015·International Journal of Cardiology·Kevin PhanStuart P Thomas
May 16, 2015·European Heart Journal·Riccardo CappatoUNKNOWN VENTURE-AF Investigators
Aug 22, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Aref A Bin AbdulhakAlan P Wimmer
Oct 16, 2015·Journal of Cardiovascular Electrophysiology·Andreas RilligRoland Richard Tilz

❮ Previous
Next ❯

Citations

May 25, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alessandro BlandinoFiorenzo Gaita
Oct 25, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Anene UkaigweGerald V Naccarrelli
Jan 10, 2018·Journal of Cardiovascular Electrophysiology·Martin EichenlaubThorsten Lewalter
Feb 9, 2017·Circulation·Amish N RavalUNKNOWN American Heart Association Clinical Pharmacology Subcommittee of the Acute Cardiac Care and General Cardiology Committee of
Jan 26, 2018·Current Treatment Options in Cardiovascular Medicine·Alan SugruePeter A Noseworthy
Jan 27, 2018·Wiener klinische Wochenschrift·Martin MartinekUNKNOWN Arbeitsgruppe Rhythmologie der Österreichischen Kardiologischen Gesellschaft
Mar 22, 2019·Scandinavian Cardiovascular Journal : SCJ·Christina AntzaVasilios Kotsis
May 20, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yuki OsakaKenzo Hirao
May 28, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yuchao SunYizhou Xu
Aug 15, 2020·Pacing and Clinical Electrophysiology : PACE·Yin-Jun MaoPin-Fang Huang
Jul 10, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jorge RomeroLuigi Di Biase
Jun 24, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Joshua E PayneSandeep Gautam
May 4, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yin-Jun MaoPin-Fang Huang
Jul 10, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Kohki NakamuraShigeru Oshima
Apr 2, 2020·Cardiovascular Drugs and Therapy·Pingping YangQinghua Wu
Apr 9, 2020·Current Pharmaceutical Design·Christos-Konstantinos AntoniouDimitrios Tousoulis
Nov 21, 2020·Pacing and Clinical Electrophysiology : PACE·Kohki NakamuraShigeto Naito
Jul 27, 2020·JACC. Clinical Electrophysiology·John W Eikelboom, Alexander P Benz
Jan 22, 2021·Journal of Cardiovascular Electrophysiology·Christopher J BradleyDavid E Haines
Feb 11, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Gemma PelargonioUNKNOWN AIAC Task Force AF Ablation
Dec 21, 2019·JACC. Clinical Electrophysiology·Jorge RomeroLuigi Di Biase
Aug 26, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Kohki NakamuraShigeto Naito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Aref A Bin AbdulhakAlan P Wimmer
Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Karuna ChilukuriHugh Calkins
© 2022 Meta ULC. All rights reserved