Aplasia of semilunar valve leaflets: two case reports and developmental aspects

Pediatric Cardiology
N G HartwigA C Gittenberger-De Groot


Two fetuses of approximately 11 weeks development with aplasia of the pulmonary as well as the aortic valve leaflets are reported. Both cases showed additional cardiac malformations. Case 1, with all leaflets missing, also had double-outlet right ventricle, hypoplastic left ventricle, large ventricular septal defect, straddling tricuspid valve, and atretic mitral valve. Case 2, with only one hypoplastic aortic valve leaflet, showed hypoplasia of the mitral valve and the left ventricle, and a subaortic ventricular septal defect. The observations made and data in the literature suggest that aplasia of semilunar valve leaflets reflects an underdevelopment of the endocardial cushion swellings at the ventriculoarterial junction, rather than resulting primarily from a malseptation of the cardiac outflow tract.


Sep 1, 1975·Chest·W H ToewsL L Kelminson
Jan 1, 1987·Heart and Vessels·K NiwaM Ando
May 1, 1986·International Journal of Cardiology·M B RossiR C Tasker
Feb 1, 1987·American Heart Journal·H J IssenbergS Bharati
May 1, 1969·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·M Z OsmanB R Girdany
Mar 1, 1984·Journal of the American College of Cardiology·F Z BiermanH Fox
Jul 1, 1980·Human Pathology·G W MooreH Kang
Sep 1, 1963·The Anatomical Record·R F SHANER


Apr 20, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R BeckerM Entezami
Oct 22, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mahmoud Suleiman, Samuel J Asirvatham
Mar 5, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Rong YuYing Yuan
Aug 1, 1997·Pacing and Clinical Electrophysiology : PACE·A F MoormanW H Lamers
Sep 27, 2016·Obstetrics & Gynecology Science·Hyeon Kyeong YeonAhm Kim
Aug 28, 2012·Fetal Diagnosis and Therapy·V FesslovaE Bonacina

Related Concepts

Aortic Valve Structure
Fetal Heart
Pulmonary Valve Structure

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2021 Meta ULC. All rights reserved