Mar 27, 1976

Aplastic anaemia: Evidence for an immunological mechanism

Lancet
J A AscensãoR Good

Abstract

The soft agar culture assay (C.F.U.-C) has been used in vitro as a measure of haemopoietic capacity of bone-marrow. In a patient with aplastic anaemia pretreatment of the patient's bone-marrow with horse anti-human-thymocyte globulin and complement (A.T.G. + C) prior to culture led to a dramatic increase in ability to form colonies in the soft agar assay; and co-culturing marrow from a normal donor and from the patient resulted in a distinct reduction in the number of expected C.F.U.-C. These findings point ot an immunological or autoimmune mechanism in this patient by selective destruction of the suppressing cells in the patient's marrow with A.T.G. and by suppression of normal myelopoiesis following addition of the patient's marrow to normal marrow.

  • References
  • Citations72

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Aplastic Anemia
T-Lymphocyte
Colony-Forming Units, Hematopoietic
Myelopoiesis
Agar
Thymocyte
Hematopoiesis, Medullary
Globulins
Culture Techniques
Visual Suppression

About this Paper

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.