PMID: 6992072May 1, 1980Paper

Aplastic and hypoplastic anemia

Pediatric Clinics of North America
J M Lipton, D G Nathan

Abstract

Aplastic anemia is an acquired or constitutional trilineage bone marrow failure with peripheral pancytopenia, evidence of cellular hypoplasia of marrow, and replacement of normal cellular elements by fat. In some cases the marrow may be hypoplastic and the peripheral cytopenia relatively mild. The condition may persist for years and result in acute leukemia. In other cases, hypoplasia may involve only a single cell line. Basic research is directed toward understanding the multitude of cells, with a view toward selective manipulation of the cells themselves, interacting hormones, or cellular regulators. Early bone marrow transplantation presently offers the most hope when compatible donors are available.

Citations

Sep 1, 1987·Annals of Tropical Paediatrics·M M LubaniA A Hassanein
Sep 1, 2006·British Journal of Haematology·Hanna T Gazda, Colin A Sieff
Mar 1, 1983·Ultrastructural Pathology·C Dell'OrboE Bianchi
Nov 25, 2000·British Journal of Haematology·C A SieffD G Nathan
Sep 1, 1987·Indian Journal of Pediatrics·V Pushpa
Apr 1, 1982·Postgraduate Medicine·T B Casale
May 1, 1982·Indian Journal of Pediatrics·V P ChoudhryA K Saraya
Jul 1, 1993·Pediatric Hematology and Oncology·R Hasan, S Inoue
Sep 1, 1989·British Journal of Haematology·P H TsaiJ M Lipton
Jan 27, 1998·Hematology/oncology Clinics of North America·O I Krijanovski, C A Sieff

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