PMID: 9433374Jan 20, 1998Paper

Aplastic anemia or aplastic preleukemic syndrome?

Annals of Hematology
T JameelM F Khattak

Abstract

The incidence of aplastic anemia appears to be relatively high in some parts of the world, including Pakistan. Since some of the etiological factors are shared by aplastic anemia and the preleukemic syndrome, there is a strong possibility that a proportion of cases of aplastic anemia may in fact be preleukemia. The study of chromosomes offers a relatively easy method of detecting cases of preleukemia, because some chromosomal abnormalities are frequently observed in this condition. Chromosomal studies were carried out in peripheral blood cell cultures of 31 patients with otherwise typical aplastic anemia. Chromosomal abnormalities were detected in 7 (22.5%) cases. The most common chromosomal abnormality detected was trisomy 8, seen in four cases. Other abnormalities detected were 22q-, t(14;22) and t(15;21), in one case each. These abnormalities have been found to be associated with AML, MDS, ALL, and NHL as well. We hypothesize that a proportion of cases of otherwise typical aplastic anemia may in fact be due to a leukemic process in evolution.

Citations

Mar 1, 2009·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Payal TripathiAchchhe Lal Vishwakerma
May 27, 2004·Leukemia & Lymphoma·Jaroslaw P Maciejewski, Carmine Selleri
Aug 31, 2010·La Revue de médecine interne·C MartinaudP Brisou
Jan 28, 2006·Mayo Clinic Proceedings·David P Steensma, John M Bennett
Jan 21, 2017·British Journal of Haematology·Natasha StanleyDaria V Babushok

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