Aplastic Anemia Secondary to Thymectomy in a Patient With Myasthenia Gravis

The Annals of Thoracic Surgery
Thomas Franchi, Jagan Rao

Abstract

It is a well-described phenomenon in the literature that a thymoma can lead to aplastic anemia, and that a thymectomy can be curative for to aplastic anemia. However, the opposite is extremely rare. We present an unusual case of a 60-year-old woman with myasthenia gravis, who was diagnosed with an incidental thymoma found on computerized tomography. Resection of the thymoma treated her myasthenia gravis but led to an aplastic anemia resistant to granulocyte colony-stimulating factor, cyclosporin, and horse antithymocyte globulin treatment. The patient received an allogenic stem cell transplant but unfortunately passed away because of complications.

References

Nov 26, 1998·Annals of Hematology·E LiozonD Bordessoule
May 15, 2009·British Journal of Haematology·Ashish BajelStephen S Opat
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Murilo Antunes de CastroMaria do Rosário Ferraz Roberti
Oct 24, 2012·Journal of Clinical Neurology·Zhi-Feng MaoMaree L Hackett
Nov 17, 2015·British Journal of Haematology·Sally B KillickUNKNOWN British Society for Standards in Haematology
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Oct 26, 2018·The New England Journal of Medicine·Neal S Young

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Citations

Oct 29, 2021·General Thoracic and Cardiovascular Surgery·Hiroki HayashidaMineo Kurokawa

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