APLP2 Modulates JNK-Dependent Cell Migration in Drosophila

BioMed Research International
Xingjun WangL Xue

Abstract

Amyloid precursor-like protein 2 (APLP2) belongs to the APP family and is widely expressed in human cells. Though previous studies have suggested a role of APLP2 in cancer progression, the exact role of APLP2 in cell migration remains elusive. Here in this report, we show that ectopic expression of APLP2 in Drosophila induces cell migration which is mediated by JNK signaling, as loss of JNK suppresses while gain of JNK enhances such phenotype. APLP2 is able to activate JNK signaling by phosphorylation of JNK, which triggers the expression of matrix metalloproteinase MMP1 required for basement membranes degradation to promote cell migration. The data presented here unraveled an in vivo role of APLP2 in JNK-mediated cell migration.

References

Feb 14, 1998·Neurobiology of Aging·C S von KochS S Sisodia
Sep 10, 1999·The Journal of Biological Chemistry·X F LiF S Yu
Jun 18, 2002·The EMBO Journal·Tatsushi IgakiMasayuki Miura
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Aug 26, 2006·Molecular Neurodegeneration·Hui Zheng, Edward H Koo
Jan 24, 2007·Developmental Biology·Michelle BeaucherAllen Shearn
Feb 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ajay SrivastavaTian Xu
Sep 4, 2007·Developmental Cell·Lei XueTian Xu
Oct 16, 2007·Molecular & Cellular Proteomics : MCP·Yu BaiGerold Schmitt-Ulms
Feb 3, 2009·Cancer Immunology, Immunotherapy : CII·Amit TuliJoyce C Solheim
Nov 30, 2010·Experimental Gerontology·Benoit BiteauHeinrich Jasper
Aug 17, 2011·Cell Research·Xianjue MaLei Xue
Jul 17, 2012·International Journal of Oncology·Haley L PetersJoyce C Solheim
Aug 23, 2012·Genetics and Molecular Research : GMR·W-Z LiL Xue
Jan 12, 2013·EMBO Reports·Vivek A RudrapatnaRoss L Cagan
May 28, 2013·FEBS Letters·S Ali M Shariati, Bart De Strooper
Mar 6, 2015·Apoptosis : an International Journal on Programmed Cell Death·Xingjun WangLei Xue
Nov 20, 2015·BioMed Research International·Jiuhong Huang, Lei Xue
Feb 4, 2016·Oncotarget·Poomy PandeyJoyce C Solheim
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xianjue MaLei Xue

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.