Apnea is associated with neurodevelopmental impairment in very low birth weight infants

Journal of Perinatology : Official Journal of the California Perinatal Association
Annie JanvierKeith J Barrington

Abstract

To determine whether apnea in preterm infants is associated with abnormal neurodevelopmental outcome. We determined the number of days that apnea and bradycardia spells were noted by the nursing staff, during the initial hospitalization of 175 preterm infants of less than <1250 g birth weight or <32 weeks gestation who had been enrolled in the follow-up program of the Royal Victoria Hospital. Multiple logistic and multiple linear regression models were constructed to determine the relationships between apnea days and neurodevelopmental impairment at 3 years of age, after correcting for gestation, sex, intrauterine growth restriction, intraventricular hemorrhage, periventricular leukomalacia, pre- and postnatal steroids, and maternal education. A total of 41 infants had neurodevelopmental impairment (Bayley MDI or PDI <70, cerebral palsy or blindness). By multiple logistic regression, an increasing number of days on which at least one apnea occurred, "total apnea days", and male sex were significantly associated with increasing probability of neurodevelopmental impairment, p<0.01, the sum of days of assisted ventilation and apnea days occurring after extubation was also associated with impairment in a separate regression model, ...Continue Reading

Associated Clinical Trials

References

Apr 1, 1991·Pediatric Research·K Barrington, N Finer
Mar 1, 1988·Early Human Development·G A LevittD R Harvey
May 1, 1986·Australian Paediatric Journal·D I TudehopeM J O'Callaghan
Oct 1, 1985·Archives of Disease in Childhood·M C Butcher-PuechD A Edwards
Oct 1, 1982·Archives of Disease in Childhood·R A Jones, D Lukeman
Nov 1, 1995·The Journal of Pediatrics·J M BolivarE Bancalari
Apr 1, 1997·The Journal of Pediatrics·M A DimaguilaM J Miller
Feb 19, 1999·Pediatric Pulmonology·P Y CheungC M Robertson

❮ Previous
Next ❯

Citations

Feb 9, 2011·European Journal of Pediatrics·Jing ZhaoDezhi Mu
Nov 16, 2012·World Journal of Pediatrics : WJP·Tao XiongDe-Zhi Mu
Jul 22, 2005·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Laura A Stokowski
Jan 20, 2011·Journal of Paediatrics and Child Health·Peter H GrayUNKNOWN Caffeine Collaborative Study Group
Mar 5, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Manuel B SchmidHans Fuchs
Apr 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin J CummingsEugene E Nattie
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J Koos
Feb 16, 2005·Biology of the Neonate·Eleanor J MolloyRichard J Martin
Jun 30, 2005·Biology of the Neonate·Richard J Martin, Jalal M Abu-Shaweesh
Oct 12, 2011·Neonatology·Richard J MartinPrabha Kc
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·Scott A SandsPhilip J Berger
Dec 10, 2009·PLoS Computational Biology·Scott A SandsPhilip J Berger
Mar 25, 2009·Journal of Perinatal Medicine·Mika ShiraishiMakiko Osawa
Sep 7, 2012·Case Reports in Neurological Medicine·Evonne LowGeraldine B Boylan
Mar 22, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·M M GreeneJ M Silvestri
Aug 16, 2014·Respiratory Physiology & Neurobiology·Ian J KidderE Fiona Bailey
Sep 7, 2014·Respiratory Physiology & Neurobiology·Kevin J Cummings
Nov 26, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·E C Eichenwald
Jun 13, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·E G Abu JawdehJ M Di Fiore
Sep 1, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·D SeidelM Knüpfer
Sep 2, 2008·European Journal of Pediatrics·Karel PaulJaroslava Dittrichová
Jan 15, 2015·Physiology & Behavior·Bieke BollenJorge Gallego
Jun 19, 2012·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Apr 13, 2011·The Journal of Pediatrics·Carl E HuntUNKNOWN Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group
Nov 3, 2010·Best Practice & Research. Clinical Anaesthesiology·Steven Michael Sale
Dec 1, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G MorietteE Lopez
Dec 17, 2009·Biological Psychology·Jorge Gallego, Boris Matrot
Jul 21, 2009·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Aug 29, 2009·Respiratory Physiology & Neurobiology·Jeanne AmielChristo Goridis
Jan 24, 2009·Clinics in Perinatology·Jean M Silvestri
Jun 13, 2008·Brain Research·Amy M BlackJerome Y Yager
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Akio IshiguroYoichi M Ito
Sep 10, 2008·Pediatric Pulmonology·Jalal M Abu-Shaweesh, Richard J Martin
Mar 7, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Kaori TanakaTetsumi Irie
Oct 6, 2015·The Journal of Pediatrics·Veronica SiljehavEric Herlenius
Mar 10, 2016·Pediatric Research·Karen FairchildJohn Kattwinkel
Nov 26, 2015·Clinics in Perinatology·Richard J MartinMichele C Walsh
Nov 20, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·J M Di FioreP MacFarlane
Nov 17, 2012·Respiratory Physiology & Neurobiology·Aida BairamVincent Joseph
Jun 28, 2011·Respiratory Physiology & Neurobiology·Jun CaiDavid Gozal
Oct 4, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S PiconeP Paolillo
Mar 17, 2015·Seminars in Fetal & Neonatal Medicine·Nelson Claure, Eduardo Bancalari
Jul 8, 2010·Early Human Development·Patricia A M van IerselMijna Hadders-Algra
Jan 19, 2015·The Journal of Pediatrics·Sanjiv B Amin, Hongyue Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.