Apnoeic oxygenation by nasal cannula during airway management in children undergoing general anaesthesia: a pilot randomised controlled trial

Perioperative Medicine
Lafi OlayanSherran Milton

Abstract

Airway management is a core clinical skill in anaesthesia. Pre-oxygenation prior to induction of anaesthesia is a standard practice to prevent desaturation. Apnoeic oxygenation in adults is effective and prolongs the time to desaturation. The effectiveness of apnoeic oxygenation in the adult is well documented; however, evidence in the paediatric is lacking. Therefore, the aim of this study was to investigate the effectiveness of apnoeic oxygenation during airway management in children. This was a pilot randomised controlled trial. Patients were randomised to receive either apnoeic oxygenation or standard care during the induction of anaesthesia. The primary outcome was the duration of safe apnoea, defined as a composite of the time to first event, either time for SpO2 to drop to 92% or time to successfully secure the airway, and the lowest SpO2 observed during airway management. Secondary outcomes were the number of patients whose SpO2 dropped below 95% and the number of patients whose SpO2 dropped below 92%. A total of 30 patients were randomised, 15 to apnoeic oxygenation and 15 to standard care. No significant difference was observed in the time to first event (p = 0.870). However, patients randomised to apnoeic oxygenation...Continue Reading

References

Nov 1, 1996·Journal of Clinical Anesthesia·F S XueG An
Jul 29, 2006·British Journal of Anaesthesia·J G Hardman, J S Wills
Aug 4, 2007·American Journal of Preventive Medicine·Robert William Sanson-FisherCate D'Este
Sep 5, 2007·Paediatric Anaesthesia·Bruno ChironMarc Laffon
Apr 29, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Issam TanoubiFrançois Donati
Apr 20, 2010·Journal of Clinical Anesthesia·Satya Krishna RamachandranChristopher R Turner
Nov 5, 2011·Annals of Emergency Medicine·Scott D Weingart, Richard M Levitan
Feb 13, 2013·Pediatrics·Ronald C SandersUNKNOWN National Emergency Airway Registry for Children Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Netwo

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Citations

Feb 6, 2020·Paediatric Anaesthesia·Mary Lyn SteinPete G Kovatsis
Aug 24, 2021·Therapeutic Advances in Infectious Disease·Pierre GoussardJacques Janson

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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