PMID: 9635107Jun 23, 1998Paper

Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis

Annals of Clinical Biochemistry
H SongK Nakashima

Abstract

It has been demonstrated that apolipoproteins found in cerebrospinal fluid (CSF) play an important role in lipid metabolism in the central nervous system (CNS). Previously we reported that CSF apo A-I levels increased with the severity of neurological damage in poliovirus-infected macaques. In the present study, apo A-I was quantitatively analysed in CSF from patients with or without neurological diseases. In controls, CSF apo A-I level was significantly higher in males; 3.83 (0.40) mg/L, mean (SEM) (n = 19) compared with females, 2.42 (0.26) mg/L (n = 23, P < 0.05). CSF apo A-I concentrations in patients with acute meningitis increased at the active stage, 7.74 (1.78) mg/L (n = 10), but returned to basal concentrations at the convalescent stage 2.72 (0.38) mg/L (n = 10), while the CSF apo A-I level in patients with other neurological diseases remained in the same range as in controls. By contrast, CSF apo E was consistently elevated at either stage of acute meningitis. Furthermore, it was found that the levels of CSF apo A-I, but not of apo E, correlated positively with CSF albumin concentrations. These findings suggest that the CSF apo A-I and apo E have different origins and may play different roles in the lipoprotein metabo...Continue Reading

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Citations

Feb 11, 2014·Cell Metabolism·Sophie StukasCheryl L Wellington
Oct 11, 2015·Biochimica Et Biophysica Acta·Jérôme RobertCheryl L Wellington
Nov 30, 2000·Current Infectious Disease Reports·H W PfisterR Paul
Jul 4, 2017·Frontiers in Pediatrics·Scott M GordonMary Catherine Harris
Sep 6, 2011·Biochimica Et Biophysica Acta·Sophie StukasCheryl L Wellington

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