PMID: 2106919Mar 12, 1990Paper

Apo A-I metabolism in cynomolgus monkeys: male-female differences

Biochimica Et Biophysica Acta
G W MelchiorK R Marotti

Abstract

Female cynomolgus monkeys have significantly higher plasma apo A-I concentrations than males (P = 0.04) and are able to maintain higher levels than the males even after consuming a high-cholesterol diet that severely depresses the apo A-I concentration in primates (P less than 0.05). The mechanism responsible for this difference was investigated by comparing apo A-I turnover (synthesis and catabolism) in males and females consuming monkey chow and in a separate group of males and females that had consumed the high-cholesterol diet for several weeks. The average length of time an apo A-I molecule remained in the plasma compartment of chow-fed monkeys was 2.62 days but decreased to 1.52 days (P less than 0.01) in animals fed the HC diet. There were no male-female differences in the residence times. The absolute turnover rate (mg/day) of apo A-I was not statistically affected by diet or sex; however, the females were substantially smaller than the males (3.8 vs. 4.8 kg; P less than 0.01) and their plasma volumes were significantly smaller than those of the males, even after correction for differences in body wt. (32.6 vs. 37.0 ml/kg, respectively; P less than 0.01). Taken together, the data indicate that females cynomolgus monkeys...Continue Reading

References

Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G W Melchior, C K Castle
Jan 1, 1985·Annals of the New York Academy of Sciences·R W MahleyK H Weisgraber
Dec 1, 1985·Atherosclerosis·G W MelchiorM T Brandon
Feb 1, 1973·The Journal of Clinical Endocrinology and Metabolism·A Rescigno, E Gurpide
Jan 1, 1983·Methods in Enzymology·G L Peterson
Jan 1, 1980·Methods in Enzymology·B A Hurn, S M Chantler

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Citations

Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·H H Newnham
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·L Nathan, G Chaudhuri
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K R MarottiG W Melchior
Nov 27, 1991·Biochimica Et Biophysica Acta·M E PapeG W Melchior
Feb 21, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Oscar Pérez-MéndezGérald Luc

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