Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans

The American Journal of Surgical Pathology
Robert B WestChih Long Lui

Abstract

Using gene microarray expression profiling, we previously found that apolipoprotein D (Apo D) was highly expressed in dermatofibrosarcoma protuberans (DFSP). In this study, we confirm that Apo D is highly and relatively specifically expressed in DFSP using immunohistochemistry. A tissue microarray containing 421 soft tissue tumors was constructed and stained with antibodies against Apo D and CD34. Cytoplasmic immunostaining for Apo D was found in 9 of 10 typical DFSPs. In addition, 3 of 3 Bednar tumors and 2 of 3 giant cell fibroblastomas stained in conventional sections. In contrast, Apo D was immunoreactive in only a very small subset of a diverse collection of other soft tissue tumors, including Malignant Fibrous Histiocytoma (MFH), glomus tumor, neurofibroma, and malignant peripheral nerve sheath tumors. Immunostains for Apo D were negative in conventional sections of 16 fibrous histiocytomas, and an additional 12 variants of fibrous histiocytoma. Digital images of all immunohistochemical and hematoxylin and eosin tissue microarray stains are available at the accompanying website (http://microarray-pubs.stanford.edu/tma_portal/apod/). We conclude that Apo D is strongly expressed in DFSPs and neural lesions and may be useful...Continue Reading

Associated Datasets

Dec 29, 2005·Matt Van De Rijn, Stanford Microarray Database

References

Aug 1, 1994·The American Journal of Surgical Pathology·M van de RijnR V Rouse
Aug 1, 1994·Human Pathology·M van de RijnR V Rouse
Oct 1, 1993·The American Journal of Surgical Pathology·S W Weiss, B J Nickoloff
Jul 1, 1994·The American Journal of Surgical Pathology·B ZelgerK W Schmid
Apr 1, 1997·The American Journal of Dermatopathology·J R Goldblum, R J Tuthill
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Jul 17, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y NatkunamM van De Rijn
Apr 20, 2002·Lancet·Torsten O NielsenMatt van de Rijn
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian P RubinJames D Bruckner
Dec 6, 2002·The American Journal of Pathology·Matt van de RijnPat Brown
Nov 25, 2003·The American Journal of Pathology·Sabine C LinnMatt van de Rijn

❮ Previous
Next ❯

Citations

Dec 20, 2005·Histopathology·R B West, M van de Rijn
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert B WestMatt van de Rijn
Jul 22, 2006·Advances in Anatomic Pathology·Torsten O Nielsen
Sep 22, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mikhail LisovskyMeera Mahalingam
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Torsten O Nielsen, Robert B West
May 17, 2011·Science China. Life Sciences·ShuLong LiFuChu He
Jul 11, 2012·International Journal of Proteomics·Tadashi KondoAkira Kawai
Jun 2, 2015·Expert Review of Anticancer Therapy·Piotr Rutkowski, Maria Debiec-Rychter
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chih Long LiuJohn P T Higgins
Nov 28, 2007·Annual Review of Pathology·Matt van de Rijn, Jonathan A Fletcher
May 28, 2005·The Journal of Pathology·Subbaya SubramanianMatt van de Rijn
Nov 1, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marina Pacheco, Torsten O Nielsen
Nov 26, 2013·Histopathology·Andrew L Folpe
May 2, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonja E SteigenTorsten O Nielsen
Jan 8, 2009·Journal of Cutaneous Pathology·Juan C Tardío
Feb 1, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Benjamin BoguckiEva A Hurst
Apr 28, 2009·Virchows Archiv : an International Journal of Pathology·Cyril Fisher
Feb 8, 2011·Head & Neck Oncology·Nikolaos AngouridakisAngelos Nikolaou
Nov 20, 2012·Oncology Letters·Alessio StivalaRosario Emanuele Perrotta
Jan 27, 2007·The American Journal of Surgical Pathology·Jefferson TerryTorsten O Nielsen
Sep 18, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tony L NgTorsten O Nielsen
Nov 4, 2008·Journal of Cutaneous Pathology·Juan C Tardío
May 17, 2012·Clinical Sarcoma Research·Emanuela PalmeriniStefano Ferrari
Jan 1, 2011·Genetics Research International·Jun NishioMasatoshi Naito
Jul 25, 2007·Annals of Surgical Oncology·Grant McArthur
Feb 12, 2009·Journal of Cancer Research and Clinical Oncology·Doreen LemmK Höffken
Sep 4, 2012·International Journal of Molecular Sciences·Hui-Ling ChenYetrib Hathout
Nov 28, 2013·Journal of Cutaneous Pathology·Ryan S BerryAimee C Smidt
Oct 24, 2012·The Kaohsiung Journal of Medical Sciences·Yi-Ting ChenChee-Yin Chai
Mar 16, 2019·Current Treatment Options in Oncology·Takeshi IwasakiYoshinao Oda
May 1, 2008·Ultrastructural Pathology·Cristina R Antonescu
Oct 19, 2005·Cancer Research·Kristin BairdPaul S Meltzer
Jun 20, 2020·Gene·Eric RassartCatherine Mounier
Oct 26, 2021·Frontiers in Physiology·Diego Sanchez, Maria D Ganfornina
Nov 17, 2012·Actas dermo-sifiliográficas·M Valdivielso-Ramos, J M Hernanz
Jan 31, 2012·Actas dermo-sifiliográficas·C Serra-GuillénO Sanmartín

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cutaneous Pathology
M P HoangC R Shea
Dermatology : International Journal for Clinical and Investigative Dermatology
Hiroshi OkitaSoji Yamazaki
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
C GarciaR E Clark
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
H-M HäfnerH Breuninger
© 2022 Meta ULC. All rights reserved