PMID: 16503867Mar 1, 2006Paper

ApoA-I Milano/phospholipid complexes emerging pharmacological strategies and medications for the prevention of atherosclerotic plaque progression

Current Drug Targets. Cardiovascular & Haematological Disorders
Sanjay Kaul, Prediman K Shah

Abstract

Epidemiologic and experimental observations suggest high density lipoprotein (HDL) has a protective effect against atherothrombotic vascular disease. These findings have stimulated considerable interest to promote HDL as a potential therapeutic strategy. Several exciting therapeutic strategies have recently emerged and currently are the focus of intense research interest. One approach is the direct administration of HDL or its components such as apolipoprotein A-I (apoA-I). Recently, much attention has focused on a naturally occurring variant of apoA-I, apoA-I(Milano) (apoA-IM) characterized by a cysteine for arginine substitution that is associated with low rates of vascular disease and significant longevity in its carriers, despite markedly reduced HDL and elevated triglyceride levels. The mutation alters the characteristics of the protein resulting in apoA-IM being functionally more effective than normal apoA-I. A number of animal and laboratory studies have demonstrated significant antiatherogenic, antiproliferative, antirestenotic, antiplatelet, antithrombotic, antiinflammatory, and antioxidant properties of apoA-IM. Furthermore, apoA-IM has been shown to promote reverse cholesterol transport, improve endothelial dysfuncti...Continue Reading

Citations

Dec 6, 2007·The American Journal of Cardiology·Prediman K Shah
Jan 30, 2015·Rejuvenation Research·Aubrey D N J de Grey
Oct 23, 2008·Expert Review of Cardiovascular Therapy·Alan T RemaleyDmitri Sviridov
Jul 9, 2008·Annals of Medicine·Sander I van LeuvenJohn J P Kastelein
Sep 12, 2006·Free Radical Biology & Medicine·Anne Negre-SalvayreRobert Salvayre

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