Abstract
Triglycerides (TG) are the initiators of the metabolic changes leading to the atherogenic dyslipidemia, which is a major inducer of atherosclerosis as a result of quantitative and qualitative changes in lipoprotein subclass distributions. We hypothesized that variation at the of APOA5 gene locus, encoding apoAV, a key regulator of TG levels, significantly affect lipoprotein subclass distributions toward a more atherogenic pattern in both hyperTG patients and dyslipemic patients. We recruited four hundred and twenty-two subjects attending a Lipid Clinic, prior to lipid-lowering treatment. We genotyped two APOA5 variants, rs662799 (-1131T>C) and rs3135506 (S19W). Circulating lipoproteins were determined by nuclear magnetic resonance (NMR). Intima-media thickness (IMT) was evaluated using B-mode ultrasound. Carriers of the rare alleles of rs662799 and rs3135506 compared to common allele homozygotes, had a significantly proatherogenic profile of the VLDL and LDL subclasses, resulting in increased concentrations of the proatherogenic subclasses, large VLDLs (+133%, p<0.001) and small LDLs (+34%, p=0.014). Significant changes in smaller HDL (+71%, p=0.032), as well as an 18% decrease in large HDL (p=0.046), were also been observed. T...Continue Reading
References
Sep 1, 1990·American Journal of Otolaryngology·J M ChowE L Applebaum
Jan 7, 1997·Circulation·S M Grundy
Oct 29, 2000·Annals of Nutrition & Metabolism·M D Ballesteros-PomarS Campiña
Mar 16, 2001·The American Journal of Cardiology·A D SnidermanB Lamarche
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 6, 2001·Science·L A PennacchioE M Rubin
Aug 26, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·D EvansF U Beil
Jan 20, 2004·Journal of Lipid Research·Philippa J TalmudMikko Syvänne
Sep 3, 2004·Journal of Lipid Research·Chao-Qiang LaiJose M Ordovas
Aug 3, 2005·Journal of Lipid Research·Yi YuLindsay A Farrer
Sep 24, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Jaroslav A Hubacek
Feb 14, 2006·Journal of Lipid Research·Roberto ElosuaChristopher J O'Donnell
May 9, 2006·Current Opinion in Lipidology·Martin AdielsJan Borén
Aug 5, 2006·Clinical Chemistry·Montse GuardiolaJosep Ribalta
Nov 18, 2006·Clinics in Laboratory Medicine·Elias J JeyarajahJames D Otvos
May 31, 2007·Diabetes Care·Sergio ValdésFrancisco Diaz Cadórniga
Nov 13, 2007·Biochimica Et Biophysica Acta·Peter GinStephen G Young
Dec 12, 2007·Diabetes Care·Earl S FordAli H Mokdad
Jan 15, 2008·Nature Genetics·Sekar KathiresanMarju Orho-Melander
Mar 12, 2008·Nature Clinical Practice. Cardiovascular Medicine·Eric de GrootJohn Jp Kastelein
May 13, 2008·Diabetes·Susan SamTheodore Mazzone
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Sep 10, 2008·Nature Clinical Practice. Cardiovascular Medicine·Jian WangRobert A Hegele
Apr 8, 2009·Annals of Internal Medicine·Stanley IpEthan M Balk
May 1, 2010·BMC Medical Genetics·María-José ArizaPedro González-Santos
May 11, 2010·Lancet·UNKNOWN Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors CollaborationJohn Danesh
Aug 5, 2010·The Journal of Rheumatology·Marta GonzàlezAntoni Castro
Jan 5, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E JarautaF Civeira
Jan 3, 2013·Biological Reviews of the Cambridge Philosophical Society·Xiao-Yan ZhengHu Yan
Citations
Dec 22, 2015·Journal of Clinical Lipidology·Montse GuardiolaJosep Ribalta
May 14, 2017·Current Atherosclerosis Reports·Montse Guardiola, Josep Ribalta
Mar 3, 2017·Nursing Research·Yen-Chun LinS Pamela K Shiao
Dec 5, 2015·Journal of Lipid Research·Bayasgalan GombojavJoohon Sung
Aug 23, 2018·Clinical Genetics·Minkyung KimJong Ho Lee
Dec 7, 2017·PloS One·Minjoo KimJong Ho Lee
Nov 20, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Minjoo KimJong Ho Lee
Jun 6, 2019·Scientific Reports·Han-Kyul KimSangdun Choi
Apr 27, 2018·Frontiers in Pharmacology·Sha HuaJianrong Zhao
Jul 22, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ivana CelapAna-Maria Simundic
Jan 24, 2019·Journal of Diabetes Research·Marica FranzagoEster Vitacolonna
Jul 3, 2021·Cells·Gilberto Vargas-AlarcónJosé Manuel Fragoso
Aug 17, 2021·Frontiers in Cardiovascular Medicine·Shuai MaXin Gao