APOA5 variants predispose hyperlipidemic patients to atherogenic dyslipidemia and subclinical atherosclerosis

Atherosclerosis
Montse GuardiolaJosep Ribalta

Abstract

Triglycerides (TG) are the initiators of the metabolic changes leading to the atherogenic dyslipidemia, which is a major inducer of atherosclerosis as a result of quantitative and qualitative changes in lipoprotein subclass distributions. We hypothesized that variation at the of APOA5 gene locus, encoding apoAV, a key regulator of TG levels, significantly affect lipoprotein subclass distributions toward a more atherogenic pattern in both hyperTG patients and dyslipemic patients. We recruited four hundred and twenty-two subjects attending a Lipid Clinic, prior to lipid-lowering treatment. We genotyped two APOA5 variants, rs662799 (-1131T>C) and rs3135506 (S19W). Circulating lipoproteins were determined by nuclear magnetic resonance (NMR). Intima-media thickness (IMT) was evaluated using B-mode ultrasound. Carriers of the rare alleles of rs662799 and rs3135506 compared to common allele homozygotes, had a significantly proatherogenic profile of the VLDL and LDL subclasses, resulting in increased concentrations of the proatherogenic subclasses, large VLDLs (+133%, p<0.001) and small LDLs (+34%, p=0.014). Significant changes in smaller HDL (+71%, p=0.032), as well as an 18% decrease in large HDL (p=0.046), were also been observed. T...Continue Reading

References

Sep 1, 1990·American Journal of Otolaryngology·J M ChowE L Applebaum
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Aug 26, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·D EvansF U Beil
Sep 24, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Jaroslav A Hubacek
May 9, 2006·Current Opinion in Lipidology·Martin AdielsJan Borén
Nov 18, 2006·Clinics in Laboratory Medicine·Elias J JeyarajahJames D Otvos
May 31, 2007·Diabetes Care·Sergio ValdésFrancisco Diaz Cadórniga
Mar 12, 2008·Nature Clinical Practice. Cardiovascular Medicine·Eric de GrootJohn Jp Kastelein
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Sep 10, 2008·Nature Clinical Practice. Cardiovascular Medicine·Jian WangRobert A Hegele
May 11, 2010·Lancet·UNKNOWN Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors CollaborationJohn Danesh
Jan 5, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E JarautaF Civeira
Jan 3, 2013·Biological Reviews of the Cambridge Philosophical Society·Xiao-Yan ZhengHu Yan

❮ Previous
Next ❯

Citations

May 14, 2017·Current Atherosclerosis Reports·Montse Guardiola, Josep Ribalta
Jul 22, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ivana CelapAna-Maria Simundic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.