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APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

bioRxiv

Aug 5, 2019

John MaciejowskiPeter J. Campbell

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Abstract

Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes. In vitro, telomere crisis instigates chromothripsis and kataegis. As the cytoplasmic nuclease TREX1 contributes to the resolution of dicentric chromosomes, we tes...read more

Mentioned in this Paper

Cytoplasm
Cytosine
Gene Rearrangement
Telomere
Chromosome Breakage
DNA Fragmentation
Carcinogenesis
TREX1 gene
APOBEC3B gene
TREX1 protein, human
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8
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APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

bioRxiv

Aug 5, 2019

John MaciejowskiPeter J. Campbell

DOI: 10.1101/725366

Abstract

Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes. In vitro, telomere crisis instigates chromothripsis and kataegis. As the cytoplasmic nuclease TREX1 contributes to the resolution of dicentric chromosomes, we tes...read more

Mentioned in this Paper

Cytoplasm
Cytosine
Gene Rearrangement
Telomere
Chromosome Breakage
17
8
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

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