APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study

Cancer Cell International
Yan DuHongbo Zhao

Abstract

Ovarian cancer is a heterogeneous disease with a high degree of genomic instability, pro-/antitumor immunity and inflammation, and remains the most lethal gynecologic cancer worldwide. APOBEC3B, a member of the AID/APOBEC family, is part of the innate immune system which plays a key role in combating exogenous infection especially viral infection. Studies have shown that APOBEC3B expression is elevated in a variety of cancer tissues and cell lines, and plays a prominent role in the genesis and evolution of various cancers. However, the clinical relevance of APOBEC3B in ovarian cancer needs to be further investigated. The current study aimed to evaluate the predictive value of APOBEC3B in ovarian cancer clinical outcome, and to explore possible molecular mechanisms contributing to ovarian cancer progression. The expression of APOBEC3B in biopsy tissue specimens from 88 ovarian cancer patients was examined using immunohistochemistry. In addition, ovarian cancer cell lines were transfected with APOBEC3B siRNA or pLenti-APOBEC3B construct. Western blotting and SRB assay were performed to explore the role of APOBEC3B in ovarian cancer. Patients were followed for a median of 74.77 months following the time of surgery. Forty-two patie...Continue Reading

References

Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M MuggiaJ M Small
Jan 14, 2009·The Journal of Experimental Medicine·Siim PauklinSvend K Petersen-Mahrt
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill
Feb 22, 2012·Clinical Obstetrics and Gynecology·Jessica Hunn, Gustavo C Rodriguez
Apr 21, 2012·American Journal of Epidemiology·Lina Steinrud MørchOjvind Lidegaard
Feb 8, 2013·Nature·Michael B BurnsReuben S Harris
Jul 16, 2013·Nature Genetics·Michael B BurnsReuben S Harris
Jul 16, 2013·Nature Genetics·Steven A RobertsDmitry A Gordenin
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Oct 25, 2013·Cancer Research·Brandon LeonardReuben S Harris
May 21, 2014·Leukemia·S RebhandlR Geisberger
Aug 16, 2014·Hormones & Cancer·Anieta M SieuwertsJohn W M Martens
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·David W CesconTak W Mak
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Mar 13, 2016·Gynecologic Oncology·Fanny DaoDouglas A Levine
Jun 3, 2017·Cell & Bioscience·Jun ZouGuang Peng
Nov 21, 2017·Cell Chemical Biology·Margaret E OlsonDaniel A Harki

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Citations

May 11, 2019·Scientific Reports·Hiroyuki YamazakiAkifumi Takaori-Kondo
Feb 12, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuan FengHongbo Zhao
Feb 10, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard G VileJose S Pulido
Dec 8, 2021·Scientific Reports·Liv B GansmoStian Knappskog

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Methods Mentioned

BETA
biopsy
transfection

Software Mentioned

SPSS

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