APOBEC3G expression and hypermutation are inversely associated with human immunodeficiency virus type 1 (HIV-1) burden in vivo.

Virology
Yordanka KourtevaRichard T D'Aquila

Abstract

APOBEC3G (A3G) and APOBEC3F (A3F) reduce Vif-negative HIV-1 provirus formation and cause disabling provirus G-to-A hypermutation in vitro. However, evidence conflicts about whether they negatively impact Vif-positive HIV-1, or only enhance virus genetic diversity, in vivo. We studied peripheral blood mononuclear cells (PBMC) from 19 antiretroviral-naïve, HIV-infected adults: 12 long-term non-progressors (LTNP) and 7 non-controllers (NC). Cells from LTNP had higher A3G and A3F mRNA levels, lower provirus burden, and more A3G-hypermutated positions in provirus sequence than cells from NC. A3G mRNA level was directly associated with its Hypermutation Index (HI) and inversely associated with provirus burden. Plasma HIV-1 RNA levels were inversely associated with A3G expression levels and with HI only among subjects who had HI>1. A3G HI was not associated with provirus burden. These results indicate that A3G deaminase-dependent activity above a threshold level, and its deaminase-independent functions, contribute to decreasing Vif-positive virus replication in vivo.

References

Jun 14, 1967·Journal of Molecular Biology·B Hirt
Oct 9, 2002·Journal of Virology·Una O'DohertyMichael H Malim
Oct 7, 2003·Nature Medicine·Mariana MarinDavid Kabat
Apr 21, 2004·Nature Structural & Molecular Biology·Qin YuNathaniel R Landau
Sep 29, 2004·Journal of Virology·Ping AnCheryl A Winkler
Nov 2, 2004·Nature Reviews. Immunology·Reuben S Harris, Mark T Liddament
Sep 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Olivier LambotteUNKNOWN SEROCO-HEMOCO Study Group
Sep 12, 2006·Nucleic Acids Research·Rodolphe SuspèneSimon Wain-Hobson
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ya-Lin ChiuWarner C Greene
Mar 22, 2007·Retrovirology·Xia JinHarold Smith
Apr 25, 2007·AIDS Research and Human Retroviruses·Gustavo H KijakFrancine E McCutchan
Feb 6, 2008·The Journal of Infectious Diseases·Kersten K KoelschJoseph K Wong
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lubbertus C F MulderViviana Simon
May 24, 2008·Virology·John P DonahueRichard T D'Aquila
Jun 26, 2008·Retrovirology·Ritu Goila-Gaur, Klaus Strebel
Jul 5, 2008·The Journal of Infectious Diseases·Nzovu K UlengaPhyllis J Kanki
Jul 16, 2008·Journal of Molecular Biology·Zhiwen HeXiao-Fang Yu
Jul 10, 2009·Journal of Virology·Fransje A KoningMichael H Malim

❮ Previous
Next ❯

Citations

Jul 19, 2013·BioMed Research International·Valdimara C Vieira, Marcelo A Soares
Jul 30, 2014·AIDS Research and Human Retroviruses·Mariana Leão de Lima-SteinLuiz Mario Janini
Nov 6, 2013·Journal of Molecular Biology·Belete A DesimmieVinay K Pathak
Oct 30, 2014·Frontiers in Microbiology·Arnaud MorisSylvain Cardinaud
Sep 17, 2015·PLoS Biology·José M CuevasRafael Sanjuán
Oct 13, 2016·PLoS Pathogens·Cristina J WittkoppMichael Emerman
May 18, 2016·PLoS Pathogens·Krista A Delviks-FrankenberryVinay K Pathak
Aug 24, 2013·Journal of Virology·Rui André Saraiva RaposoSatish K Pillai
Jul 3, 2021·Frontiers in Microbiology·Terumasa IkedaHesham Nasser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.