Abstract
A worldwide public health problem is chronic kidney disease (CKD) presenting alarming epidemiological data. It currently affects about 10% of the adult population worldwide and has a high mortality rate. It is now known that oxidative stress represents one of the most important mechanisms in its pathophysiology, from the early stages to the terminal phase. Oxidation increases inflammation and reduces the capacity of NO• to relax vascular smooth muscle, in part by decreasing bioavailability of tetrahydrobiopterin (BH4), leading to endothelial dysfunction and high blood pressure, and due to the limited effectiveness of existing treatments, new drugs are needed to prevent and/or treat these mechanisms. The aim of this study was to test apocynin in a 5/6 nephrectomy mouse model of CKD to investigate whether its known antioxidant effect can improve the disease outcome. This effect results from the inhibition of NADPH oxidase and consequently a reduced production of the superoxide anion ([Formula: see text]). Animals were divided into five groups: sham, 5/6 nephrectomy only, and 5/6 nephrectomy followed by treatment with captopril, losartan or apocynin. The parameters evaluated were blood pressure and markers of oxidative stress ([Fo...Continue Reading
References
Apr 9, 1999·Vaccine·L A HodgsonJ F Smith
Nov 2, 2002·Hypertension·Carlene A HamiltonAnna F Dominiczak
Apr 15, 2003·The Journal of Biological Chemistry·Nermin KuzkayaSergey Dikalov
Oct 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian-Mei Li, Ajay M Shah
Jul 5, 2006·Heart Failure Reviews·Michel de Lorgeril, Patricia Salen
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Dec 15, 2006·Archives of Biochemistry and Biophysics·Valdecir F XimenesMário S Galhiane
Jul 10, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cécile CouchoudBénédicte Stengel
Aug 20, 2008·Fertility and Sterility·Reda MahfouzAshok Agarwal
Nov 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Anjali S GodboleGhassan S Kassab
Jun 16, 2009·Bioorganic & Medicinal Chemistry·Mauricio Mora-PaleJonathan S Dordick
Jun 16, 2010·Arquivos brasileiros de cardiologia·Luiza A RabêloWalkyria O Sampaio
Jan 12, 2011·Renal Failure·Monica G Arellano-MendozaBruno Escalante
Jan 28, 2012·Cardiovascular Therapeutics·Jennifer StreeterFrancis J Miller
Jun 28, 2013·Journal of Human Hypertension·S MennuniM Volpe
Jul 11, 2013·Oxidative Medicine and Cellular Longevity·Sunil JoshiSaeed R Khan
Mar 11, 2016·Oxidative Medicine and Cellular Longevity·Xiaolu JinJianxin Liu