Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

Journal of Neuroinflammation
Duy-Khanh DangHyoung-Chun Kim

Abstract

Activation of NADPH oxidase (PHOX) plays a critical role in mediating dopaminergic neuroinflammation. In the present study, we investigated the role of PHOX in methamphetamine (MA)-induced neurotoxic and inflammatory changes in mice. We examined changes in mitogen-activated protein kinases (MAPKs), mitochondrial function [i.e., mitochondrial membrane potential, intramitochondrial Ca(2+) accumulation, mitochondrial oxidative burdens, mitochondrial superoxide dismutase expression, and mitochondrial translocation of the cleaved form of protein kinase C delta type (cleaved PKCδ)], microglial activity, and pro-apoptotic changes [i.e., cytosolic cytochrome c release, cleaved caspase 3, and terminal deoxynucleotidyl transferase dUDP nick-end labeling (TUNEL) positive populations] after a neurotoxic dose of MA in the striatum of mice to achieve a better understanding of the effects of apocynin, a non-specific PHOX inhibitor, or genetic inhibition of p47phox (by using p47phox knockout mice or p47phox antisense oligonucleotide) against MA-induced dopaminergic neurotoxicity. Phosphorylation of extracellular signal-regulated kinases (ERK1/2) was most pronounced out of MAPKs after MA. We observed MA-induced phosphorylation and membrane tran...Continue Reading

References

Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Dec 16, 1998·Neurobiology of Disease·P KlivenyiM Flint Beal
Feb 7, 2002·Neurotoxicology·T R Guilarte
Oct 17, 2002·Endothelium : Journal of Endothelial Cell Research·David K JohnsonJames A Holland
Nov 21, 2002·Cellular and Molecular Life Sciences : CMLS·P V Vignais
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Du-Chu WuSerge Przedborski
Aug 2, 2003·Journal of Pharmacological Sciences·Taizo KitaToshikatsu Nakashima
Aug 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui-Ming GaoJau-Shyong Hong
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrey Y AbramovMichael R Duchen
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akira NakajimaToshitaka Nabeshima
May 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·David M ThomasDonald M Kuhn
Jun 12, 2004·Apoptosis : an International Journal on Programmed Cell Death·T Kuwabara, S Imajoh-Ohmi
Nov 16, 2004·Annals of the New York Academy of Sciences·Masato AsanumaNorio Ogawa
Dec 14, 2004·The Biochemical Journal·Yvonne Groemping, Katrin Rittinger
Feb 3, 2005·Journal of Neurochemistry·David M Thomas, Donald M Kuhn
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZhangJing Zhang
May 5, 2005·Experimental Neurology·Andreas Hald, Julie Lotharius
Aug 6, 2005·Progress in Neurobiology·Michelle L Block, Jau-Shyong Hong
Jun 17, 2006·The Journal of Clinical Investigation·Pham My-Chan DangJamel El-Benna
Dec 5, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZhangHyoung-Chun Kim
Dec 21, 2006·Nature Reviews. Neuroscience·Michelle L BlockJau-Shyong Hong
Apr 24, 2007·Neurotoxicity Research·Jean Lud CadetJohnalyn Lyles
Jan 19, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ashley D ReynoldsHoward E Gendelman
May 3, 2008·Journal of Proteome Research·Firas H KobeissyKevin K W Wang
May 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshimoto SekineJean L Cadet
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li QianPatrick M Flood

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Citations

Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Peter G WellsLutfiya Miller-Pinsler
Mar 1, 2017·Archives of Pharmacal Research·Eun-Joo ShinHyoung-Chun Kim
Jul 16, 2020·Biomolecules & Therapeutics·Buyun KimByoungduck Park
Jul 22, 2018·Journal of Applied Toxicology : JAT·Huynh Nhu MaiHyoung-Chun Kim
Apr 17, 2020·Archives of Toxicology·Kwang-Hyun HurChoon-Gon Jang
Mar 14, 2020·Metabolomics : Official Journal of the Metabolomic Society·Poonam RanaNamas Chandra
Nov 25, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hai-Quyen TranHyoung-Chun Kim
Dec 10, 2019·Neurotoxicology·Sabrini SabriniLouise Curley
Mar 11, 2021·Drug Metabolism Reviews·Shreya R SavlaYogesh A Kulkarni
May 22, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dieu Hien PhanHyoung-Chun Kim
Jul 22, 2021·Archives of Pharmacal Research·Eun-Joo ShinHyoung-Chun Kim
Jun 30, 2021·Experimental Neurology·Subramaniam JayanthiJean Lud Cadet

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Datasets Mentioned

BETA
AB002663.1

Methods Mentioned

BETA
GTPase
antisense oligonucleotide
gene knockout
electrophoresis
PCR
transgenic

Software Mentioned

ImageJ
PhotoCapt MW

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