APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.

Neurology
Shahram OveisgharanDavid A Bennett

Abstract

To examine the association of the APOE ε2ε4 genotype with incident Alzheimer disease (AD), mild cognitive impairment (MCI), cognitive decline, and AD pathology in older adults. We used data from 2,151 older adults of European ancestry who were free of dementia at baseline and underwent structured annual clinical evaluation in a longitudinal study for incident AD and MCI, and cognitive decline. Postmortem examination in decedents documented pathologic AD and quantified β-amyloid and neurofibrillary tangles. Participants were stratified into 4 groups based on APOE genotyping: ε2ε4, ε4 (ε4ε4, ε4ε3), ε2 (ε2ε2, ε2ε3), with ε3ε3 carriers serving as the reference group. We used Cox proportional hazards models to examine the association of APOE genotype with incident AD and MCI. Linear mixed-effect models were used to examine the association with cognitive decline. Logistic and linear regression models were used to examine AD pathology. All the models controlled for age, sex, and education. Of the 2,151 participants included in this study, ε2ε4 accounted for 2.1%, ε3/4 and 4/4 21.8%, ε2/3 and 2/2 14.0%, and ε3ε3 62.1%. We did not observe a difference in the risk of AD for ε2ε4 compared to ε3ε3. In cases without cognitive impairment at ...Continue Reading

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Citations

Jan 16, 2019·Annual Review of Public Health·Bryan D James, David A Bennett
May 3, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shahram OveisgharanAron S Buchman
Sep 5, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Alexandra J WeigandUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 20, 2018·Acta Neuropathologica·Shahram OveisgharanDavid A Bennett
Jan 27, 2019·Lipids in Health and Disease·Ghulam HussainTao Sun
Feb 2, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Gemma SalvadóUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 23, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Juliet FocklerRachel L Nosheny
Mar 30, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Zeev MeinerJoe Verghese
May 30, 2021·Scientific Reports·Aron S BuchmanDavid A Bennett
Apr 16, 2021·Neurology·Shahram OveisgharanJulie A Schneider

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