APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Usman SaeedMario Masellis

Abstract

Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. We studied 298 patients (AD = 250, DLB = 48; 38 autopsy-confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-ε4 with hippocampal volume and learning/memory phenotypes, irrespective of diagnosis. Across the AD/DLB spectrum: (1) hippocampal volumes were smaller with increasing APOE-ε4 dosage (no genotype × diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-ε4 carriers, and (3) APOE-ε4 carriers performed worse on long-delay free word recall. These findings provide evidence that APOE-ε4 is linked to hippocampal atrophy and learning/memory phenotypes across the AD/DLB spectrum, which could be useful as biomarkers of disease progression in therapeutic trials of mixed disease.

Associated Clinical Trials

Feb 27, 2013·Dr. Sandra E Black

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E MasliahL Mucke
Apr 26, 2003·Science·Benoit I GiassonVirginia M-Y Lee
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Walter J BrechtYadong Huang
May 27, 2005·Neurobiology of Aging·Olga PletnikovaJuan C Troncoso
Sep 27, 2005·Neurobiology of Aging·Michael BassoChristopher H van Dyck
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert W MahleyYadong Huang
Feb 3, 2007·Brain : a Journal of Neurology·Jennifer L WhitwellClifford R Jack
Dec 2, 2008·Brain : a Journal of Neurology·E C MorminoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Sandra BlackJuan Bilbao
Apr 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nicola FilippiniClare E Mackay
May 7, 2009·Brain : a Journal of Neurology·Christos DavatzikosSusan M Resnick
Sep 11, 2009·Annals of Neurology·Julie A SchneiderDavid A Bennett
Jul 1, 2011·Science Translational Medicine·Joseph M CastellanoDavid M Holtzman
Jan 11, 2013·Alzheimer's Research & Therapy·Benjamin LamSandra E Black
Feb 14, 2013·PloS One·Christopher A HostageUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 15, 2013·JAMA Neurology·Debby TsuangCyrus P Zabetian
Sep 3, 2014·JAMA Neurology·Ignacio F MataCyrus P Zabetian
Oct 29, 2014·Acta Neuropathologica·John F CraryPeter T Nelson
Nov 12, 2014·BMC Medicine·Johannes Attems, Kurt A Jellinger
Apr 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Myria PetrouKirk A Frey
May 20, 2015·JAMA Neurology·Eun Joo ChungJohn C Morris
Jul 25, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Joel RamirezUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 7, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rodolfo SavicaMichelle M Mielke

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Citations

Jul 6, 2019·Advanced Materials·Lie WangHuisheng Peng
Oct 3, 2019·Neurology·Saira Saeed MirzaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 12, 2018·Current Neurology and Neuroscience Reports·Tatiana OrmeJose Bras
Oct 6, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Tetiana GorbachLars Nyberg
Jan 25, 2021·Alzheimer's Research & Therapy·Jagan A PillaiJames B Leverenz
Jan 27, 2021·Annual Review of Pathology·Caitlin S LatimerThomas J Montine
Nov 13, 2020·Frontiers in Neurology·Usman SaeedMario Masellis
Jun 23, 2020·Ageing Research Reviews·Zuo-Teng WangJin-Tai Yu
Mar 2, 2021·Journal of Alzheimer's Disease : JAD·Tamara ShinerNoa Bregman
Jul 10, 2021·Neurobiology of Aging·Jin Ho JungByoung Seok Ye
Jun 18, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Gillian CoughlanCheryl Grady
Aug 14, 2021·CNS Neuroscience & Therapeutics·Feifei ZangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative*
Aug 24, 2021·Journal of Alzheimer's Disease : JAD·Katie J SchenningNabil J Alkayed

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