APOE ɛ4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke

Journal of Alzheimer's Disease : JAD
Emilio WerdenAmy Brodtmann

Abstract

The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. However, its relationship with cognition and brain volume after stroke is not clear. We compared cognition and medial temporal lobe volumes in APOEɛ4 carriers and non-carriers in the first year after ischemic stroke. We sampled 20 APOEɛ4 carriers and 20 non-carriers from a larger cohort of 135 ischemic stroke participants in the longitudinal CANVAS study. Participants were matched on a range of demographic and stroke characteristics. We used linear mixed-effect models to compare cognitive domain z-scores (attention, processing speed, executive function, verbal and visual memory, language, visuospatial function) and regional medial temporal lobe volumes (hippocampal, entorhinal cortex) between groups at each time-point (three, 12-months post-stroke), and within groups across time-points. APOE gene single nucleotide polymorphisms (SNPs; rs7412, rs429358) were genotyped on venous blood. APOEɛ4 carriers and non-carriers did not differ on any demographic, clinical, or stroke variable. Carriers performed worse than non-carriers in verbal memory at three months post-stroke (p = 0.046), but were better in executive function a...Continue Reading

References

Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Nov 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·H HénonD Leys
Dec 22, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C GeroldiG B Frisoni
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yawu LiuHannu J Aronen
Nov 24, 2004·Neurology·M R FarlowH C Charles
Mar 24, 2005·Dementia and Geriatric Cognitive Disorders·Josephine BarnesNick C Fox
Jul 30, 2005·Stroke; a Journal of Cerebral Circulation·E RowanR A Kenny
Feb 18, 2006·Dementia and Geriatric Cognitive Disorders·P S SachdevA S Zagami
Mar 8, 2006·Journal of the International Neuropsychological Society : JINS·G M S NysE H F De Haan
Apr 12, 2006·Archives of Neurology·Christiane ReitzRichard Mayeux
May 17, 2007·American Journal of Epidemiology·Roger MånssonSean Hennessy
Jun 6, 2007·Journal of Geriatric Psychiatry and Neurology·Larry BaumKa Sing Wong
Jun 29, 2007·Dementia and Geriatric Cognitive Disorders·Annelies E van der VliesWiesje M van der Flier
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Julie S SnowdenDavid Mann
Mar 3, 2009·Brain : a Journal of Neurology·N SchuffUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 2, 2009·Brain : a Journal of Neurology·Liselore SnaphaanFrank-Erik de Leeuw
Jun 6, 2009·Dementia and Geriatric Cognitive Disorders·Jørgen WagleKnut Engedal
Jul 17, 2009·The New England Journal of Medicine·Richard J CaselliEric M Reiman
Dec 5, 2009·International Journal of Geriatric Psychiatry·Jørgen WagleKnut Engedal
Apr 9, 2010·Dementia and Geriatric Cognitive Disorders·Yi-Fang ChuangPeter P Zandi
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·David A WolkUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 22, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Bradford C DickersonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 28, 2011·Neurology·S BlumA M Brickman
Dec 31, 2011·Stroke; a Journal of Cerebral Circulation·Elizabeth GemmellRaj N Kalaria
Mar 13, 2012·Neurobiology of Aging·Gene E AlexanderJames R Moeller
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Apr 12, 2012·Stroke; a Journal of Cerebral Circulation·Jian ZhangJinsheng Zeng
Apr 24, 2012·Journal of Clinical Neurology·Beom Joon KimHee-Joon Bae
Aug 7, 2012·Journal of Neurology·Robert HurfordDavid J Werring
Nov 15, 2012·Stroke; a Journal of Cerebral Circulation·Abdel DouiriCharles D A Wolfe
Nov 16, 2012·PloS One·Laurence O'DwyerHarald Hampel
Feb 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luye QinSunghee Cho
Mar 20, 2014·Neuroscience Research·Kaori Takehara-Nishiuchi
Mar 25, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Perminder S SachdevHenry Brodaty
Jun 1, 2014·PloS One·Emily N ManningUNKNOWN Alzheimer's Disease NeuroImaging Initiative
Jun 5, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Amy BrodtmannToby Cumming
Oct 24, 2014·Frontiers in Human Neuroscience·Amanda Marie DiBattistaAdam E Green

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