APOE ε4 is associated with higher levels of CSF SNAP-25 in prodromal Alzheimer's disease

Neuroscience Letters
Shanshan Wangfor Alzheimer’s Disease Neuroimaging Initiative

Abstract

The underlying mechanism of apolipoprotein E ε4 (APOE ε4) in the pathogenesis of Alzheimer's disease (AD) remains elusive. We hypothesize that synaptic function is differentially affected by APOE isoforms. Levels of CSF SNAP-25 were compared between APOE ε4 carriers and noncarriers in 55 participants with normal cognition, 75 patients with mild cognitive impairment (MCI), and 16 patients with mild AD dementia. We investigated relationships between SNAP-25 levels and age, gender, education, CSF Aβ42, and tau protein. We found that levels of SNAP-25 in CSF were substantially greater in APOE ε4 carriers compared to noncarriers with MCI. There was no significant difference in SNAP-25 levels between APOE ε4 carriers and noncarriers with normal cognition or AD. CSF SNAP-25 levels were associated with MMSE and CSF Aβ and tau levels. In summary, APOE ε4 may affect CSF SNAP levels in MCI patients, suggesting an important role of APOE ε4 in synaptic dysfunction leading to AD.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 18, 1997·Biochemical and Biophysical Research Communications·S ShimohamaJ Kimura
Jun 1, 2000·Journal of the Neurological Sciences·C I SzeL J Martin
Oct 26, 2002·Science·Dennis J Selkoe
Mar 1, 2003·Neurobiology of Disease·Armand SaviozGeneviève Leuba
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Daniel Ungar, Frederick M Hughson
Sep 10, 2004·The European Journal of Neuroscience·Qiuling HouLei Yu
Jan 15, 2005·Neurobiology of Disease·Barbara L TrommerMary Jo LaDu
Feb 3, 2005·Neurobiology of Disease·Chunsheng WangPatrick M Sullivan
Jun 28, 2005·Neurobiology of Aging·Seth LoveShelley J Allen
Jul 28, 2006·Biochemical and Biophysical Research Communications·Qiu-Ling HouBao-Ming Li
Feb 15, 2007·Journal of Neurochemistry·Niamh C O'SullivanKeith J Murphy
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·David M HoltzmanGuojun Bu
Dec 12, 2012·Neuron·Robert W Mahley, Yadong Huang
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Nov 25, 2014·Molecular Neurodegeneration·Ann BrinkmalmAnnika Öhrfelt
Jan 7, 2015·Neuropathology and Applied Neurobiology·Lindsey I SinclairSeth Love
Feb 28, 2016·Lancet·Philip ScheltensWiesje Maria Van der Flier
Mar 31, 2016·Neuroscience·M Panpalli AtesM A Ergun
Jun 21, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Xiaoyan SunUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 5, 2017·Annual Review of Neuroscience·Michel GoedertR Anthony Crowther

❮ Previous
Next ❯

Citations

Sep 12, 2020·Biomarker Insights·Elena CamporesiHenrik Zetterberg
May 5, 2020·Frontiers in Cellular Neuroscience·Catarina PerdigãoCláudia Guimas Almeida
Jul 17, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rachel L HensonAnne M Fagan
Oct 9, 2020·Expert Review of Proteomics·Sonia MazzucchiFilippo Baldacci
Nov 21, 2020·International Journal of Molecular Sciences·Bin Zhou, Masanori Fukushima
Feb 2, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Feng ChenYan Wang
Mar 26, 2021·Neurobiology of Aging·Omar H ButtUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

© 2022 Meta ULC. All rights reserved