APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study.

Age and Ageing
H A D KeageMRC Cognitive Function and Ageing Study

Abstract

dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate on incident dementia risk over 10 years. participants come from MRC CFAS, a multi-centre longitudinal population-based study of ageing in England and Wales. Three follow-up waves of data collection were used: 2, 6 and 10 years. Logistic regressions were undertaken to investigate associations between APOE (n = 955) and ACE (n = 856) alleles/genotypes and incident dementia. Two types of control groups were used: non-demented and highly functioning non-demented. Results were back-weighted. compared to APOE epsilon3, epsilon2 conferred protection of odds ratio (OR) = 0.3 (95% confidence interval, CI = 0.1-0.6) and epsilon4 risk of OR = 2.9 (95% CI = 1.7-4.9) for incident dementia. Compared to epsilon3/epsilon3, the epsilon3/epsilon4 and epsilon4/epsilon4 genotypes conferred risks of OR = 3.6 (95% CI = 1.8-7.3) and OR = 7.9 (95% CI = 1.6-39.2), respectively. The epsilon3/epsilon2 genotype protected against dementia (OR = 0.2, 95% CI = 0.1-0.7), and epsilon2/epsilon2 had a similar protective effect but with wide CIs (OR ...Continue Reading

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Citations

Sep 19, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Anna ZettergrenIngmar Skoog
Dec 6, 2016·International Journal of Molecular Sciences·Meredith Harrison-BrownRichard Banati
Feb 12, 2010·Annals of the New York Academy of Sciences·Ilo E Leppik, Angela K Birnbaum
Feb 7, 2019·Pediatric Research·Haibo LiUNKNOWN China Child and Adolescent Cardiovascular Health (CCACH) Collaboration Group
May 22, 2018·Journal of Alzheimer's Disease : JAD·Sally HunterCarol Brayne

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Methods Mentioned

BETA
genotyping

Software Mentioned

AGECAT

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