APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis

Molecular Neurobiology
Md Sahab UddinGhulam Md Ashraf

Abstract

Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau protein. People carrying the APOE4 allele are at high risk of AD concerning the ones carrying the ε3 allele, while the ε2 allele abates risk. ApoE isoforms exert a central role in controlling the transport of brain lipid, neuronal signaling, mitochondrial function, glucose metabolism, and neuroinflammation. Regardless of widespread indispensable studies, the appropriate function of APOE in AD etiology stays ambiguous. Existing proof recommends that the disparate outcomes of ApoE isoforms on Aβ accretion and clearance have a distinct function in AD pathogenesis. ApoE-lipoproteins combine diverse cell-surface receptors to transport lipids and moreover to lipophilic Aβ peptide, that is believed to begin deadly events that generate neurodegeneration in the AD. ApoE has great influence in tau pathogenesis, tau-mediated neurodegeneration, and neuroinflammation, as well as α-synucleinopathy, lipid metabolism, and synaptic plasticity despite the presence of Aβ pathology. ApoE4 shows the deleterious effect for AD while the lack of ApoE4 is defensive. Therapeutic...Continue Reading

References

Mar 1, 1995·The Biochemical Journal·E M CastanoB Frangione
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Nov 1, 1996·Chemistry & Biology·S J WoodR Wetzel
Jun 20, 1998·The Journal of Biological Chemistry·D S HowlandD G Flood
Mar 17, 1999·The Journal of Clinical Investigation·D M HoltzmanS M Paul
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·K R BalesS M Paul
Feb 3, 2000·Human Molecular Genetics·H HamanakaS C Fujita
Feb 24, 2001·Annals of the New York Academy of Sciences·M C IrizarryB T Hyman
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HuangR W Mahley
Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M RiemenschneiderA Kurz
Jul 12, 2002·Journal of Neuroscience Research·B TeterG M Cole
Sep 26, 2003·The Journal of Biological Chemistry·John R LynchDaniel T Laskowitz
Aug 18, 2004·Journal of Neurochemistry·Michael C IrizarryG William Rebeck
Sep 24, 2004·Human Molecular Genetics·Nicholas J BrayMichael C O'Donovan
Nov 24, 2004·The Journal of Biological Chemistry·Radosveta P KoldamovaJohn S Lazo
Jan 25, 2005·Neuroscience Letters·Asad Vaisi RayganiTayebeh Pourmotabbed
Mar 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D FryerDavid M Holtzman
Mar 19, 2005·Journal of Neurochemistry·Hyang-Sook HoeG William Rebeck

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Citations

Sep 18, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Md Sahab UddinMst Marium Begum
Jul 16, 2019·The Journal of Pharmacy and Pharmacology·Seetha HarilalBijo Mathew
Oct 13, 2019·Current Pharmaceutical Design·Md Tanvir KabirGhulam Md Ashraf
Jun 13, 2019·Molecular Neurodegeneration·Ramsey NajmYadong Huang
Apr 24, 2020·Current Topics in Medicinal Chemistry·Md Tanvir KabirGhulam Md Ashraf
Apr 24, 2020·Current Pharmaceutical Design·Anmol DograJasjeet K Narang
Sep 15, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daniela CamporezFlavia de Paula
Mar 10, 2020·The Journal of Pharmacy and Pharmacology·Md Sahab UddinGhulam Md Ashraf
Mar 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Md Sahab UddinLotfi Aleya
Apr 21, 2020·Mediators of Inflammation·Sajad ChamaniAmirhossein Sahebkar
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Abdullah Al MamunMohamed M Abdel-Daim
May 5, 2020·Frontiers in Aging Neuroscience·Bruno Dutra ArboMariana Appel Hort
Mar 8, 2020·Molecular and Cellular Biochemistry·Zhu LiJin-Tao Li
Oct 18, 2019·Frontiers in Cell and Developmental Biology·Md Sahab Uddin, Md Tanvir Kabir
May 10, 2020·International Journal of Molecular Sciences·Md Tanvir KabirMohamed M Abdel-Daim
Jul 4, 2020·BMC Medical Research Methodology·Marco PiccininniTobias Kurth
Jul 28, 2020·Nature Reviews. Drug Discovery·Stephen C CunnaneMark J Millan
May 16, 2020·Oxidative Medicine and Cellular Longevity·Md Sahab UddinMohamed M Abdel-Daim
Mar 12, 2020·Neurotoxicity Research·Abdullah Al MamunGhulam Md Ashraf
Nov 11, 2020·Nature Reviews. Neurology·Carolin A M KoriathSimon Mead
Nov 28, 2020·Brain Structure & Function·Sandra Sánchez-SarasúaAna María Sánchez-Pérez
Dec 9, 2020·Ophthalmic Genetics·Marcelo Luís OcchiuttoVital Paulino Costa
Aug 20, 2019·European Journal of Medicinal Chemistry·Rajesh KumarBijo Mathew
May 1, 2020·International Immunopharmacology·Md Sahab UddinGhulam Md Ashraf
Dec 1, 2019·The Science of the Total Environment·Md Sahab UddinLotfi Aleya
Apr 22, 2020·Brain Research Bulletin·Seetha HarilalBijo Mathew
Apr 23, 2020·Pharmacology & Therapeutics·Eva Gil-MartinsRenata Silva
Mar 2, 2021·Neural Regeneration Research·Chinthalapally V Rao, Hiroshi Y Yamada
Mar 12, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sakthi Jothi Muthu, Prakash Seppan
Mar 10, 2021·Biology of Sex Differences·Shounak Baksi, Ajay Pradhan
Jun 20, 2020·Journal of the Neurological Sciences·Md Sahab UddinGhulam Md Ashraf

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Methods Mentioned

BETA
transgenic
lipidation
flow cytometry

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